HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	31980649, 35271311, 32707033, 33961781, 36931259, unassigned2173, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 393
+	Hs
		909461 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Xl
		223344 O57468_XENLA (1-244): 4.25e-141: 397: 63.12		Q804T2_XENLA (1-333): 1.36e-120: 367: 19.94
+	Hs
		647862 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		734905 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	Hs
		647860 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		625306 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681770 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (49-334): 2.22e-120: 359: 21.50
+	Hs
		734904 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		625296 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681766 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	At
		965298 14332_ARATH (4-244): 1.39e-141: 398: 61.32		MPK7_ARATH (67-383): 1.52e-119: 352: 18.71
+	Hs
		909447 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	Dm
		954998 1433E_DROME (1-243): 1.58e-140: 396: 63.37		DSOR1_DROME (12-392): 4.19e-114: 340: 61.42
+	Hs
		909502 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		909512 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK3_HUMAN (50-369): 2.6e-109: 331: 33.23
+	Hs
		904507 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		153111 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49