HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36931259, 17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 487
+	Hs
		909502 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		909512 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		904517 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	At
		965291 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CDPK1_ARATH (5-446): 2.41e-136: 408: 20.64
+	At
		802001 14334_ARATH (4-244): 5e-140: 395: 60.91		CDPK1_ARATH (5-446): 2.41e-136: 408: 20.64
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (1-463): 1.46e-132: 394: 18.68
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (1-463): 1.46e-132: 394: 18.68
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (1-463): 1.46e-132: 394: 18.68
+	Xl
		223344 O57468_XENLA (1-244): 4.25e-141: 397: 63.12		Q804T2_XENLA (29-451): 8.66e-125: 381: 21.74
+	Mm
		910231 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		MARK3_MOUSE (29-425): 5.7e-124: 380: 22.44
+	Hs
		647862 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK3_HUMAN (29-451): 4.09e-123: 378: 21.32
+	Hs
		909730 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68
+	Mm
		905331 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		MARK3_MOUSE (29-425): 5.7e-124: 380: 22.44
+	Hs
		647860 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MARK3_HUMAN (29-451): 4.09e-123: 378: 21.32
+	Hs
		904766 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68
+	Hs
		568616 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90
+	Hs
		904516 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK2_HUMAN (8-300): 1.44e-118: 359: 40.26
+	Hs
		904514 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK1_HUMAN (3-305): 1.66e-117: 357: 40.91
+	Hs
		909810 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MINK1_HUMAN (10-336): 5.97e-73: 252: 42.32
+	Hs
		909881 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		M4K1_HUMAN (17-281): 2.36e-74: 252: 45.22