Protein: MBD4
Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)

Gene: MBD4
Organism: Homo sapiens
Interactions: 81
UniProt ID: O95243

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003696 - satellite DNA binding
GO:0004520 - DNA endonuclease activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

331666

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.740

High

331641

MLH1
DNA mismatch repair protein Mlh1

5

0

Small-scale

0.691

High

331642

HD
Huntingtin

2

1

High-throughput

0.643

High

331625

TRI27
Zinc finger protein RFP

2

1

Small-scale

0.632

High

331620

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.608

High

331678

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.573

High

331619

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

331679

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

4

Small-scale

0.561

High

331677

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.541

High

331681

TRI55
Tripartite motif-containing protein 55

1

4

High-throughput

0.541

High

74422

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

8

High-throughput

0.536

High

331632

APC
Adenomatous polyposis coli protein

1

5

High-throughput

0.536

High

331635

S100P
Protein S100-P

1

7

High-throughput

0.536

High

331639

S10A7
Protein S100-A7

1

7

High-throughput

0.536

High

331673

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

330532

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.513

High

331621

KPCB
Protein kinase C beta type

1

0

High-throughput

0.513

High

331626

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

331631

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.513

High

331633

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

331637

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

216357

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

5

High-throughput

0.508

High

246361

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.508

High

331658

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.508

High

331683

DNM3B
DNA

1

4

Small-scale

0.501

High

331680

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.493

High

331616

CO3
Complement C3

1

3

High-throughput

0.489

High

331622

INVO
Involucrin

1

3

High-throughput

0.489

High

331638

ILEU
Leukocyte elastase inhibitor

1

1

High-throughput

0.489

High

331644

SPB4
Serpin B4

1

1

High-throughput

0.489

High

331671

S1A7A
Protein S100-A7A

1

7

High-throughput

0.489

High

331668

CDCA2
Cell division cycle-associated protein 2

1

0

High-throughput

0.486

High

331656

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

259246

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

331617

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

331623

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

9

Small-scale

0.479

High

331627

NUCL
Nucleolin

1

2

Small-scale

0.479

High

331628

H1T
Histone H1t

1

1

Small-scale

0.479

High

331629

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

Small-scale

0.479

High

331640

RL4
Large ribosomal subunit protein uL4

1

1

Small-scale

0.479

High

331646

RS3A
Small ribosomal subunit protein eS1

1

1

Small-scale

0.479

High

331647

RL26
Large ribosomal subunit protein uL24

1

1

Small-scale

0.479

High

331648

RL15
Large ribosomal subunit protein eL15

1

1

Small-scale

0.479

High

331649

RS8
Small ribosomal subunit protein eS8

1

1

Small-scale

0.479

High

331650

RS18
Small ribosomal subunit protein uS13

1

1

Small-scale

0.479

High

331651

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.479

High

331652

H4
Histone H4

1

1

High-throughput

0.479

High

331653

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

331654

RL23
Large ribosomal subunit protein uL14

1

1

Small-scale

0.479

High

331657

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.479

High

331659

H31
Histone H3.1

1

5

High-throughput

0.479

High

331661

H33
Histone H3.3

1

5

High-throughput

0.479

High

331662

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

Small-scale

0.479

High

331663

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

331664

DHX9
ATP-dependent RNA helicase A

1

9

Small-scale

0.479

High

331667

NONO
Non-POU domain-containing octamer-binding protein

1

8

Small-scale

0.479

High

331672

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

331674

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

331676

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

Small-scale

0.479

High

331684

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

331675

TFG
Protein TFG

1

5

High-throughput

0.470

High

301281

WFS1
Wolframin

1

1

High-throughput

0.470

High

220051

XRCC2
DNA repair protein XRCC2

1

0

Small-scale

0.458

High

331655

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.458

High

331685

RWDD3
RWD domain-containing protein 3

1

0

Small-scale

0.458

High

75643

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

105010

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

331645

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

6

High-throughput

0.437

High

69463

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.407

High

331624

ARY2
Arylamine N-acetyltransferase 2

2

0

High-throughput

0.316

High

331665

FADD
FAS-associated death domain protein

1

0

Small-scale

0.305

High

331634

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.282

High

261575

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

331630

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

331660

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.279

Low

331669

P20D1
N-fatty-acyl-amino acid synthase/hydrolase PM20D1

1

0

High-throughput

0.279

Low

331670

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

331682

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

331636

GRN
Progranulin

1

0

High-throughput

0.268

Low

331643

RL28
Large ribosomal subunit protein eL28

1

0

Small-scale

0.249

Low

331618

IGHG3
Immunoglobulin heavy constant gamma 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025