HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1116
+	Hs
		910040 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		909680 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		904714 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		904684 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MAGI3_HUMAN (1-1116): 3.96e-94: 331: 9.76
+	Hs
		982109 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		MAGI3_HUMAN (1-1116): 3.96e-94: 331: 9.76
+	Dm
		955008 1433E_DROME (1-243): 1.58e-140: 396: 63.37		Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37
+	Mm
		910246 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		Q3ZB59_MOUSE (169-641): 7.79e-50: 190: 13.11
+	Hs
		910172 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		909582 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38
+	Hs
		905271 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		905015 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Mm
		910229 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		MPRIP_MOUSE (97-790): 2.36e-40: 164: 11.98
+	Hs
		910043 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		909703 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		910027 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		905130 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		904740 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		905112 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		125318 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		904987 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93