HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: E2AK3 (Q9NZJ5)
Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)
Gene: EIF2AK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 1116
+	Hs
		682160 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		AKT2_HUMAN (635-1110): 3.81e-122: 385: 14.08
+	Dm
		715095 UBE2N_DROME (5-152): 6.43e-62: 190: 34.21		AKT1_DROME (538-1110): 1.8e-120: 385: 13.83
+	Zm
		8408 A0A1D6ENM7_MAIZE (4-151): 8e-73: 218: 29.61		Q6RXY1_MAIZE (813-1104): 7.42e-109: 351: 20.27
+	Hs
		568615 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		KAPCA_HUMAN (804-1112): 1.48e-115: 363: 14.95
+	Hs
		908517 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		KCC1A_HUMAN (808-1103): 1.63e-101: 326: 19.48
+	Hs
		908498 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		KCC2D_HUMAN (814-1092): 2.52e-99: 325: 23.02
+	Hs
		374010 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		RAF1_HUMAN (672-1083): 9.3e-80: 276: 20.58
+	Hs
		908859 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		NEK9_HUMAN (884-1113): 8.97e-18: 91.3: 28.16
+	Hs
		851392 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		NEK4_HUMAN (918-1072): 1.43e-15: 84: 30.25
+	Hs
		585438 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		E2AK2_HUMAN (579-658): 1.79e-11: 70.1: 46.34