HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 947
+	Hs
		681770 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		910063 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		PAK6_HUMAN (70-672): 1.33e-125: 397: 17.46
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (345-930): 7.1e-125: 397: 14.17
+	Hs
		909507 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK1_HUMAN (374-909): 2.62e-124: 390: 17.48
+	Rn
		871214 1433E_RAT (1-255): 4.87e-154: 430: 100.00		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (381-854): 1.26e-129: 401: 17.35
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (381-854): 1.26e-129: 401: 17.35
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (381-854): 1.26e-129: 401: 17.35
+	Hs
		568616 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Hs
		861687 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		PLK1_HUMAN (406-781): 1.04e-106: 345: 26.87
+	Sc
		419854 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		SNF1_YEAST (396-846): 2.96e-117: 374: 18.13
+	Sc
		419824 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		SNF1_YEAST (396-846): 2.96e-117: 374: 18.13
+	Hs
		909590 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KS6A2_HUMAN (319-657): 9e-97: 322: 21.49
+	Hs
		909502 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		909513 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		910191 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K2_HUMAN (386-626): 1.28e-24: 112: 33.60
+	Hs
		909957 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		909512 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK3_HUMAN (405-647): 1.3e-20: 98.2: 31.73
+	At
		788620 14333_ARATH (1-253): 3.45e-147: 413: 74.12		M3K2_ARATH (392-647): 1.96e-23: 108: 30.77