Protein: MED1
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)

Gene: MED1
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q15648

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0000902 - cell morphogenesis
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1151297

MED4
Mediator of RNA polymerase II transcription subunit 4

10

1

Small-scale

0.974

High

1151299

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.923

High

881530

CDK8
Cyclin-dependent kinase 8

17

11

Small-scale

0.765

High

789502

PPARG
Peroxisome proliferator-activated receptor gamma

18

20

Small-scale

0.760

High

48961

MED19
Mediator of RNA polymerase II transcription subunit 19

11

1

Small-scale

0.758

High

396185

ESR1
Estrogen receptor

9

20

Small-scale

0.757

High

1151276

MED12
Mediator of RNA polymerase II transcription subunit 12

10

20

Small-scale

0.755

High

1151298

MED17
Mediator of RNA polymerase II transcription subunit 17

10

1

Small-scale

0.754

High

1151290

MED10
Mediator of RNA polymerase II transcription subunit 10

9

1

Small-scale

0.754

High

533289

THA
Thyroid hormone receptor alpha

9

20

Small-scale

0.753

High

1151307

MED13
Mediator of RNA polymerase II transcription subunit 13

9

4

Small-scale

0.752

High

239580

MED14
Mediator of RNA polymerase II transcription subunit 14

8

14

Small-scale

0.751

High

543513

VDR
Vitamin D3 receptor

8

20

Small-scale

0.750

High

1151295

MED20
Mediator of RNA polymerase II transcription subunit 20

7

2

Small-scale

0.748

High

1108347

MED21
Mediator of RNA polymerase II transcription subunit 21

7

1

Small-scale

0.747

High

1151293

MED28
Mediator of RNA polymerase II transcription subunit 28

7

1

Small-scale

0.747

High

219488

MED7
Mediator of RNA polymerase II transcription subunit 7

7

1

Small-scale

0.747

High

282383

MED24
Mediator of RNA polymerase II transcription subunit 24

8

2

Small-scale

0.747

High

1151283

MED15
Mediator of RNA polymerase II transcription subunit 15

7

12

Small-scale

0.746

High

1151292

CDK19
Cyclin-dependent kinase 19

7

9

High-throughput

0.746

High

1151314

MED16
Mediator of RNA polymerase II transcription subunit 16

7

1

Small-scale

0.746

High

666835

CCNC
Cyclin-C

8

5

Small-scale

0.744

High

1151265

MED25
Mediator of RNA polymerase II transcription subunit 25

8

6

Small-scale

0.744

High

335993

MED26
Mediator of RNA polymerase II transcription subunit 26

6

1

Small-scale

0.738

High

259999

BRD4
Bromodomain-containing protein 4

7

17

Small-scale

0.738

High

1151259

MED27
Mediator of RNA polymerase II transcription subunit 27

6

1

Small-scale

0.733

High

1151279

MED8
Mediator of RNA polymerase II transcription subunit 8

6

1

Small-scale

0.733

High

1151280

MED30
Mediator of RNA polymerase II transcription subunit 30

6

1

Small-scale

0.733

High

1151310

MED23
Mediator of RNA polymerase II transcription subunit 23

6

4

Small-scale

0.733

High

1151315

MED31
Mediator of RNA polymerase II transcription subunit 31

5

1

Small-scale

0.722

High

1151300

MED29
Mediator of RNA polymerase II transcription subunit 29

8

0

Small-scale

0.721

High

1151264

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

4

Small-scale

0.718

High

1151302

MED11
Mediator of RNA polymerase II transcription subunit 11

5

1

Small-scale

0.718

High

520586

RARA
Retinoic acid receptor alpha

5

20

Small-scale

0.717

High

287791

MED6
Mediator of RNA polymerase II transcription subunit 6

7

0

Small-scale

0.714

High

1151291

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

Small-scale

0.709

High

404079

GCR
Glucocorticoid receptor

5

20

Small-scale

0.707

High

625820

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.705

High

1149684

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.699

High

1151274

ESR2
Estrogen receptor beta

4

20

Small-scale

0.693

High

1151247

MED1
Mediator of RNA polymerase II transcription subunit 1

4

15

Small-scale

0.680

High

413900

P53
Cellular tumor antigen p53

3

9

Small-scale

0.678

High

1134805

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.667

High

1151268

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

20

High-throughput

0.667

High

667313

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

3

Small-scale

0.656

High

958950

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

1

Small-scale

0.656

High

1151306

DPOLL
DNA polymerase lambda

3

1

High-throughput

0.656

High

1151269

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.646

High

520079

ANDR
Androgen receptor

2

20

Small-scale

0.641

High

1151275

KAT2A
Histone acetyltransferase KAT2A

3

20

Small-scale

0.633

High

833950

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.629

High

912181

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.622

High

976093

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

0

High-throughput

0.622

High

621883

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.611

High

919987

PLK1
Serine/threonine-protein kinase PLK1

2

9

High-throughput

0.611

High

787873

SRBP1
Sterol regulatory element-binding protein 1

2

11

Small-scale

0.608

High

192818

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

372118

MYC
Myc proto-oncogene protein

2

17

Small-scale

0.595

High

933943

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.594

High

588786

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.586

High

558162

XRCC6
X-ray repair cross-complementing protein 6

2

3

High-throughput

0.584

High

979716

H4
Histone H4

2

5

High-throughput

0.584

High

1060606

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.584

High

1151277

FBXW7
F-box/WD repeat-containing protein 7

2

7

Small-scale

0.584

High

590431

GATA1
Erythroid transcription factor

1

13

Small-scale

0.581

High

400884

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

9

High-throughput

0.571

High

662429

GATA2
Endothelial transcription factor GATA-2

1

13

Small-scale

0.561

High

700826

PIT1
Pituitary-specific positive transcription factor 1

1

11

Small-scale

0.561

High

1055605

GABPA
GA-binding protein alpha chain

1

20

Small-scale

0.561

High

1151284

TGS1
Trimethylguanosine synthase

1

1

Small-scale

0.561

High

1151304

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

2

Small-scale

0.561

High

1151258

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.552

High

354991

CHK2
Serine/threonine-protein kinase Chk2

1

2

Small-scale

0.536

High

188682

BIRC5
Baculoviral IAP repeat-containing protein 5

1

2

High-throughput

0.536

High

283482

TAD2A
Transcriptional adapter 2-alpha

1

6

High-throughput

0.536

High

1151260

FXL19
F-box/LRR-repeat protein 19

1

4

High-throughput

0.536

High

1028214

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.534

High

886890

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.527

High

1141138

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.515

High

1151278

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.515

High

1151257

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

508022

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

691034

1433T
14-3-3 protein theta

1

20

Small-scale

0.501

High

691752

MK03
Mitogen-activated protein kinase 3

1

4

Small-scale

0.501

High

1095499

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.501

High

1109272

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.501

High

1130567

NCOA6
Nuclear receptor coactivator 6

1

17

Small-scale

0.501

High

1151249

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.501

High

1151317

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

Small-scale

0.501

High

1085426

SRBP2
Sterol regulatory element-binding protein 2

1

12

Small-scale

0.500

High

335241

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.494

High

1136213

EMC2
ER membrane protein complex subunit 2

1

13

High-throughput

0.489

High

1151282

SPAG5
Sperm-associated antigen 5

1

14

High-throughput

0.489

High

1151316

TRRAP
Transformation/transcription domain-associated protein

1

7

Small-scale

0.484

High

168696

CSKP
Peripheral plasma membrane protein CASK

1

8

High-throughput

0.481

High

913942

RBM5
RNA-binding protein 5

1

4

High-throughput

0.481

High

163111

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

129116

MEN1
Menin

1

5

High-throughput

0.479

High

143011

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

157422

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.479

High

241778

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

326336

SCAF4
SR-related and CTD-associated factor 4

1

8

High-throughput

0.479

High

342884

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

345875

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

347715

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

411990

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

474009

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487352

PARP1
Poly [ADP-ribose] polymerase 1

1

14

Small-scale

0.479

High

533347

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.479

High

621648

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.479

High

628789

TBP
TATA-box-binding protein

1

1

Small-scale

0.479

High

674176

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

695551

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

714147

PML
Protein PML

1

20

High-throughput

0.479

High

722970

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.479

High

754856

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

768279

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

862163

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

872362

SOX2
Transcription factor SOX-2

1

15

Small-scale

0.479

High

897835

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

904763

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

986444

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

995422

TPM4
Tropomyosin alpha-4 chain

1

6

High-throughput

0.479

High

995617

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

998353

H31
Histone H3.1

1

19

High-throughput

0.479

High

1008744

RED1
Double-stranded RNA-specific editase 1

1

12

High-throughput

0.479

High

1016887

H33
Histone H3.3

1

19

High-throughput

0.479

High

1025106

TF2B
Transcription initiation factor IIB

1

6

Small-scale

0.479

High

1029844

RUNX1
Runt-related transcription factor 1

1

4

High-throughput

0.479

High

1037797

IRF8
Interferon regulatory factor 8

1

10

Small-scale

0.479

High

1045322

TF65
Transcription factor p65

1

11

High-throughput

0.479

High

1087757

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088852

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

1097309

CBX3
Chromobox protein homolog 3

1

10

High-throughput

0.479

High

1102172

ATM
Serine-protein kinase ATM

1

7

Small-scale

0.479

High

1103188

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

1133425

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1151248

TRIP4
Activating signal cointegrator 1

1

2

High-throughput

0.479

High

1151251

DCAF6
DDB1- and CUL4-associated factor 6

1

10

High-throughput

0.479

High

1151253

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

16

High-throughput

0.479

High

1151254

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

10

High-throughput

0.479

High

1151263

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1151266

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1151267

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1151270

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1151271

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

1151272

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1151273

TOPB1
DNA topoisomerase 2-binding protein 1

1

10

High-throughput

0.479

High

1151281

QKI
KH domain-containing RNA-binding protein QKI

1

2

High-throughput

0.479

High

1151286

T22D3
TSC22 domain family protein 3

1

1

Small-scale

0.479

High

1151287

TBX5
T-box transcription factor TBX5

1

8

High-throughput

0.479

High

1151288

EPAS1
Endothelial PAS domain-containing protein 1

1

14

Small-scale

0.479

High

1151301

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1151305

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1151308

HERC5
E3 ISG15--protein ligase HERC5

1

6

Small-scale

0.479

High

1151309

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

1151311

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

1151312

SATB2
DNA-binding protein SATB2

1

1

Small-scale

0.479

High

1151303

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.460

High

283603

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

319149

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.458

High

324892

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

569108

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.458

High

787749

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

912063

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

974934

TYB4
Thymosin beta-4

1

0

High-throughput

0.458

High

983658

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1151250

FBX43
F-box only protein 43

1

0

High-throughput

0.458

High

1151294

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1151296

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

95746

E5RFK5
Cyclin-C

1

4

High-throughput

0.445

High

253955

LPXN
Leupaxin

1

7

High-throughput

0.445

High

777287

AHR
Aryl hydrocarbon receptor

1

15

Small-scale

0.445

High

1151252

Q5JQP4
DNA polymerase

1

1

High-throughput

0.445

High

1151313

TR150
Thyroid hormone receptor-associated protein 3

1

10

Small-scale

0.445

High

1085073

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.439

High

1151289

AKAP9
A-kinase anchor protein 9

1

13

High-throughput

0.439

High

387526

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.437

High

464160

TPM2
Tropomyosin beta chain

1

5

High-throughput

0.437

High

1151255

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.437

High

1151261

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1151262

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1151285

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

76425

B4DUB1
cyclin-dependent kinase

1

10

High-throughput

0.407

High

352627

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

476436

IBP1
Insulin-like growth factor-binding protein 1

1

0

Small-scale

0.249

Low

1151256

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

506010

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025