HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: NUAK2 (Q9H093)
NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)
Gene: NUAK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36736316, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0034504 - protein localization to nucleus GO:0035556 - intracellular signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 628
+	Mm
		910266 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NUAK1_MOUSE (3-628): 3.21e-161: 478: 54.03
+	Hs
		229938 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NUAK1_HUMAN (3-628): 2.28e-155: 463: 53.95
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (6-613): 9.9e-150: 453: 26.75
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (6-613): 1.81e-146: 444: 26.79
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (4-613): 3.07e-145: 441: 26.14
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (5-625): 8.68e-145: 438: 24.85
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (5-625): 3.05e-141: 430: 25.54
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (5-625): 6.42e-140: 427: 25.25
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (17-611): 8.46e-139: 424: 27.03
+	Hs
		909916 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK4_HUMAN (17-611): 2.32e-138: 422: 27.19
+	Dm
		90534 1433E_DROME (1-254): 2.95e-146: 411: 82.69		E1JGN0_DROME (12-625): 1.53e-133: 421: 26.12
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (28-377): 2.89e-137: 411: 32.11
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (28-377): 2.89e-137: 411: 32.11
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (28-377): 2.89e-137: 411: 32.11
+	Sc
		419854 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		SNF1_YEAST (52-487): 2.4e-127: 390: 33.26
+	Sc
		419824 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		SNF1_YEAST (52-487): 2.4e-127: 390: 33.26
+	Rn
		871214 1433E_RAT (1-255): 4.87e-154: 430: 100.00		AAPK1_RAT (35-302): 1.32e-70: 240: 46.49
+	Hs
		909507 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK1_HUMAN (35-302): 1.31e-70: 240: 46.49
+	Hs
		871354 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK2_HUMAN (41-302): 5.22e-68: 233: 45.46