HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	35271311, 36736316, 16306228
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001764 - neuron migration GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 795
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (1-795): 0: 767: 94.34
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (1-795): 0: 682: 64.14
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (2-795): 0: 672: 64.55
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (1-795): 0: 662: 62.87
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (1-795): 0: 643: 60.78
+	Dm
		90534 1433E_DROME (1-254): 2.95e-146: 411: 82.69		E1JGN0_DROME (8-795): 0: 594: 48.17
+	Hs
		909916 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (1-795): 0: 569: 49.01
+	Hs
		909567 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MELK_HUMAN (56-795): 1.01e-161: 485: 25.30
+	Hs
		910013 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK2_HUMAN (45-766): 2.35e-142: 444: 28.27
+	Hs
		910187 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK3_HUMAN (36-620): 8.16e-139: 444: 36.67
+	Hs
		910071 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SNRK_HUMAN (55-794): 1.35e-143: 442: 22.91
+	Hs
		883214 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Rn
		871214 1433E_RAT (1-255): 4.87e-154: 430: 100.00		AAPK1_RAT (34-579): 1.58e-142: 433: 28.29
+	Hs
		871354 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		909507 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10
+	Sc
		419854 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		SNF1_YEAST (40-484): 6.82e-140: 428: 36.38
+	Sc
		419824 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		SNF1_YEAST (40-484): 6.82e-140: 428: 36.38