HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: PAK5 (Q9P286)
Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)
Gene: PAK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 36931259
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 719
+	Hs
		910063 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		PAK6_HUMAN (1-718): 4.95e-171: 508: 44.37
+	Hs
		909957 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K3_HUMAN (76-699): 1.76e-147: 445: 21.05
+	Mm
		910275 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DCLK2_MOUSE (96-719): 4.55e-141: 433: 19.55
+	Hs
		909811 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DCLK2_HUMAN (96-719): 9.15e-139: 427: 19.64
+	Hs
		166549 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DCLK1_HUMAN (93-719): 1.75e-136: 421: 19.47
+	Mm
		910345 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DCLK1_MOUSE (93-719): 2.37e-133: 413: 19.45
+	Hs
		681770 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKT1_HUMAN (307-716): 1.36e-131: 399: 19.77
+	Hs
		910191 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		M3K2_HUMAN (76-700): 1.59e-127: 394: 20.94
+	Sc
		712973 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		FPK1_YEAST (12-714): 3e-138: 430: 17.41
+	At
		965291 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CDPK1_ARATH (329-716): 8.68e-128: 394: 25.18
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (420-705): 1.32e-127: 389: 25.00
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (420-705): 1.32e-127: 389: 25.00
+	At
		802001 14334_ARATH (4-255): 2.51e-145: 408: 73.62		CDPK1_ARATH (329-716): 8.68e-128: 394: 25.18
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (420-705): 1.32e-127: 389: 25.00
+	Hs
		909502 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK4_HUMAN (426-717): 2.11e-120: 370: 37.42
+	Hs
		909512 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK3_HUMAN (420-718): 4.61e-119: 367: 37.54
+	At
		788694 14335_ARATH (2-255): 3.04e-141: 398: 68.75		CDPK1_ARATH (329-716): 8.68e-128: 394: 25.18
+	Hs
		909590 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KS6A2_HUMAN (447-714): 4.31e-113: 359: 24.30
+	Hs
		330944 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		PAK4_HUMAN (1-314): 7.21e-41: 160: 28.35
+	Sc
		713000 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		STE20_YEAST (11-253): 1.26e-15: 83.2: 15.14