HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	24722339, 30804502, 35271311, 12626569
Identification Methods	pull down, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 488
+	Mm
		918237 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Dm
		950398 H4_DROME (1-103): 4.51e-48: 150: 99.03		HDAC1_DROME (5-472): 0: 653: 77.92
+	Mm
		140249 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		917226 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	At
		886854 H4_ARATH (1-103): 3.47e-48: 150: 98.06		HDA6_ARATH (1-467): 0: 578: 57.02
+	Hs
		177252 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Sc
		356336 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RPD3_YEAST (5-422): 0: 577: 60.95
+	Sp
		140573 H4_SCHPO (18-103): 4.87e-42: 135: 89.54		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Sc
		356604 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HOS2_YEAST (11-430): 5.02e-174: 498: 47.18
+	Hs
		917872 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Sc
		356643 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HDA1_YEAST (9-330): 1.24e-121: 373: 27.56
+	Hs
		918077 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04