Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1
Interactor 2: RGAP1 (Q9H0H5)
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Gene: RACGAP1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.82 | 1.00 | 0.906 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25486482, 29764989, 19468300, 19468302 |
| Identification Methods | enzymatic study, affinity chromatography technology, protein kinase assay, far western blotting, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~Pkinase |
| Common GO terms | GO:0000281 - mitotic cytokinesis GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005819 - spindle GO:0005829 - cytosol and 4 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
