HitPredict

Interactor 1: COPA (P53621)
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
Gene: COPA

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1224 Hs			1 1620
+	Hs
		773692 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		477221 COPA_HUMAN (1-1224): 0: 1304: 100.00		ROS1_HUMAN (1039-1461): 3.97e-112: 397: 37.75
+	Rn
		81619 B5DFK1_RAT (1-1224): 0: 1297: 98.37		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Rn
		108140 G3V6T1_RAT (1-1224): 0: 1291: 98.28		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		411639 COPA_HUMAN (1-1224): 0: 1304: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		921910 COPA_HUMAN (1-1224): 0: 1304: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541407 COPA_HUMAN (1-1224): 0: 1304: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		179598 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		477214 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		ROS1_HUMAN (1039-1461): 3.97e-112: 397: 37.75
+	Hs
		439667 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Hs
		650078 LIS1_HUMAN (198-526): 4.28e-34: 138: 16.96		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Hs
		1038487 WDR3_HUMAN (303-477): 8.15e-20: 98.2: 8.81		TIE2_HUMAN (954-1389): 7.26e-115: 393: 29.30
+	Hs
		411476 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		773523 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541371 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		411528 LIS1_HUMAN (198-526): 4.28e-34: 138: 16.96		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		411686 WDR5_HUMAN (520-631): 1.42e-09: 63.1: 10.35		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07