HitPredict

Interactor 1: D3DMF6 (D3DMF6)
Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25)
Gene: wnd

Interactor 2: RHO1 (P48148)
Ras-like GTP-binding protein Rho1
Gene: RHO1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25961917
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 950 Dm			1 192
+	Hs
		212016 M3K13_HUMAN (9-910): 3.95e-133: 426: 34.43		CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89
+	Hs
		988698 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73
+	Hs
		840944 ABL2_HUMAN (14-895): 4.74e-122: 401: 16.82		RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73
+	Hs
		1015775 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21
+	Hs
		581282 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16
+	Hs
		955580 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89
+	Hs
		580912 ABL2_HUMAN (14-895): 4.74e-122: 401: 16.82		RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16
+	Hs
		840940 ABL2_HUMAN (14-895): 4.74e-122: 401: 16.82		CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89
+	Hs
		953667 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		RAC3_HUMAN (1-179): 1.2e-73: 221: 57.54
+	Hs
		978297 TAOK3_HUMAN (112-919): 8.55e-126: 404: 14.84		RHOB_HUMAN (1-190): 3.26e-73: 220: 82.11
+	Hs
		840939 ABL2_HUMAN (14-895): 4.74e-122: 401: 16.82		RAC3_HUMAN (1-179): 1.2e-73: 221: 57.54
+	Hs
		988474 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73
+	Hs
		1015546 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21
+	Hs
		962195 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53
+	Hs
		581132 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16
+	Hs
		466323 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94
+	Hs
		955318 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89
+	Hs
		466114 MARK3_HUMAN (86-756): 1.59e-119: 383: 17.54		RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94
+	Hs
		953523 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RAC3_HUMAN (1-179): 1.2e-73: 221: 57.54
+	Hs
		978108 MARK2_HUMAN (79-795): 1.88e-120: 387: 15.46		RHOB_HUMAN (1-190): 3.26e-73: 220: 82.11