HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: HDAC7 (Q8WUI4)
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)
Gene: HDAC7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.615

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, mammalian protein protein interaction trap
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 952
+	Hs
		545523 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Hs
		892506 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Hs
		894252 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Hs
		900733 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		HDAC7_HUMAN (1-952): 0: 1051: 100.00
+	Mm
		925822 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		Q9JM08_MOUSE (518-951): 5.78e-159: 475: 20.00
+	Hs
		545545 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		HDA10_HUMAN (520-943): 1.36e-152: 467: 36.39
+	Hs
		925697 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HDAC6_HUMAN (443-951): 2.96e-115: 383: 30.33
+	Hs
		894550 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		HDAC6_HUMAN (443-951): 2.96e-115: 383: 30.33