HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: CYFP2 (Q96F07)
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Gene: CYFIP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0030031 - cell projection assembly and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 1278
+	Hs
		545555 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		892535 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		951231 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		900789 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		CYFP2_HUMAN (1-1278): 0: 2164: 100.00
+	Hs
		925386 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Mm
		925800 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CYFP1_MOUSE (1-1277): 0: 2032: 85.68
+	Hs
		545463 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		1184655 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		892449 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		951104 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		894162 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Hs
		900624 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		CYFP1_HUMAN (1-1277): 0: 2040: 85.92
+	Mm
		1143609 RHOC_MOUSE (5-192): 8.68e-75: 224: 57.45		CYFP1_MOUSE (1-1277): 0: 2032: 85.68
+	Dm
		776913 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		CYFIP_DROME (1-1277): 0: 1898: 64.75
+	At
		1105134 RAC4_ARATH (4-177): 2.4e-80: 239: 64.37		PIR_ARATH (5-1264): 0: 1510: 28.95
+	At
		1105163 RAC5_ARATH (4-177): 1.11e-79: 237: 64.94		PIR_ARATH (5-1264): 0: 1510: 28.95
+	At
		1105123 RAC3_ARATH (2-180): 3.62e-72: 218: 65.92		PIR_ARATH (5-1264): 0: 1510: 28.95