HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: PDE3A (Q14432)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Gene: PDE3A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15161933
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 1141
+	Hs
		646886 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PDE3A_HUMAN (1-1141): 0: 1483: 100.00
+	Hs
		927008 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		909520 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		646867 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		904523 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Hs
		981979 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		PDE3B_HUMAN (121-1126): 0: 1145: 45.33
+	Mm
		926778 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		PDE4D_MOUSE (394-1074): 1.01e-177: 541: 21.92
+	Mm
		926779 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		PDE1B_MOUSE (516-1127): 3.99e-148: 456: 23.21
+	Mm
		926801 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		PDE1A_MOUSE (614-1125): 3.79e-134: 420: 24.29
+	Hs
		872399 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PDE1A_HUMAN (614-1106): 4.53e-134: 420: 25.20
+	Hs
		927028 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		909546 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		927558 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		683334 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		PDE7A_HUMAN (638-1054): 2.28e-114: 365: 23.22
+	Hs
		910054 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		647301 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		683736 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85
+	Hs
		905142 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		PDE7B_HUMAN (647-1062): 6.63e-111: 355: 21.85