HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: M3K11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Gene: MAP3K11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33875576
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 847
+	Hs
		926918 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K9_HUMAN (44-825): 5.7e-161: 499: 46.37
+	Hs
		909438 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		M3K9_HUMAN (44-825): 5.7e-161: 499: 46.37
+	Hs
		646793 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		M3K9_HUMAN (44-825): 5.7e-161: 499: 46.37
+	Hs
		926946 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		909462 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		646816 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		927141 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Hs
		909655 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Hs
		646976 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Hs
		337420 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ABL1_HUMAN (31-847): 1.28e-120: 393: 20.94
+	Hs
		337416 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ABL1_HUMAN (31-847): 1.28e-120: 393: 20.94
+	Hs
		926964 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ACK1_HUMAN (61-847): 1.02e-118: 386: 20.77
+	At
		965327 14332_ARATH (3-239): 6.89e-143: 401: 65.15		PBS1_ARATH (43-469): 5.89e-127: 390: 21.62
+	Hs
		337355 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ABL1_HUMAN (31-847): 1.28e-120: 393: 20.94
+	Hs
		646845 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		M3K12_HUMAN (58-810): 3.8e-123: 393: 26.28
+	At
		1277300 14337_ARATH (2-238): 9.2e-142: 399: 62.66		SERK1_ARATH (3-426): 2.47e-118: 374: 20.13
+	At
		965320 14332_ARATH (3-239): 6.89e-143: 401: 65.15		BAK1_ARATH (3-429): 7.26e-118: 372: 20.44
+	Hs
		927591 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K20_HUMAN (114-461): 3.54e-113: 365: 37.11
+	Hs
		910094 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		M3K20_HUMAN (114-461): 3.54e-113: 365: 37.11
+	At
		788521 14333_ARATH (3-239): 1.48e-141: 398: 64.73		PBL9_ARATH (76-381): 9.99e-118: 365: 21.93