HitPredict

Interactor 1: ATN1 (P54259)
Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)
Gene: ATN1

Interactor 2: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	24999758, 16713569
Identification Methods	proximity labelling technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1190 Hs			1 656
+	Hs
		341541 ATN1_HUMAN (1-1190): 1.01e-149: 482: 100.00		EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02
+	Hs
		1032963 MDC1_HUMAN (99-1036): 6.17e-15: 82.6: 10.11		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		903443 SMCA4_HUMAN (216-592): 1.32e-10: 68.3: 13.53		RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05
+	Hs
		1032965 NCOA6_HUMAN (1-1021): 3.47e-12: 73.4: 9.30		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		903326 SMCA4_HUMAN (216-592): 1.32e-10: 68.3: 13.53		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		319093 SC24D_HUMAN (162-388): 1.98e-10: 67.5: 24.32		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		1033167 CIC_HUMAN (25-764): 2.05e-09: 64.4: 10.38		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		1033338 PCLO_HUMAN (664-1133): 5.72e-09: 63: 11.81		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Hs
		925711 SC24C_HUMAN (69-393): 6.67e-09: 62.4: 16.87		EWS_HUMAN (1-656): 1.53e-47: 179: 100.00
+	Mm
		1021845 SMCA4_MOUSE (33-392): 7.61e-09: 62.6: 12.36		EYA1_MOUSE (3-277): 2.58e-40: 157: 22.50
+	Hs
		341654 CIC_HUMAN (25-764): 2.05e-09: 64.4: 10.38		EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02
+	Hs
		775083 MDC1_HUMAN (99-1036): 6.17e-15: 82.6: 10.11		FUS_HUMAN (55-545): 1.16e-31: 131: 30.35
+	Hs
		775084 NCOA6_HUMAN (1-1021): 3.47e-12: 73.4: 9.30		FUS_HUMAN (55-545): 1.16e-31: 131: 30.35
+	Hs
		774935 SMCA4_HUMAN (216-592): 1.32e-10: 68.3: 13.53		FUS_HUMAN (55-545): 1.16e-31: 131: 30.35
+	Dm
		465902 Q9VLS7_DROME (198-1147): 2.29e-14: 80.7: 12.03		CO4A1_DROME (378-655): 1.54e-22: 105: 15.68
+	Mm
		266844 ATX2_MOUSE (5-403): 5.97e-09: 62.6: 9.70		FUS_MOUSE (66-545): 4.21e-27: 117: 32.08
+	Dm
		1481049 Q9VLS7_DROME (198-1147): 2.29e-14: 80.7: 12.03		Q9VMV5_DROME (3-357): 2.66e-15: 82.2: 12.08
+	Hs
		124642 CIC_HUMAN (25-764): 2.05e-09: 64.4: 10.38		EYA2_HUMAN (27-278): 1.49e-18: 91.3: 20.16