HitPredict

Interactor 1: E9PYG6 (E9PYG6)
RAS p21 protein activator 1
Gene: Rasa1

Interactor 2: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.739

Property	Details
Experiments	10428862, 20697350, 9697832
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Mm			1 412
+	Hs
		235043 RASA1_HUMAN (1-1038): 0: 782: 94.17		DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04
+	Mm
		93305 E9PYG6_MOUSE (1-1038): 0: 812: 100.00		DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51
+	Rn
		842411 RASA1_RAT (1-1038): 0: 801: 98.65		DOK1_RAT (6-394): 7.16e-109: 330: 34.66
+	Hs
		596429 RASA1_HUMAN (1-1038): 0: 782: 94.17		DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11
+	Mm
		250956 Q91YX7_MOUSE (103-289): 1.77e-16: 86.7: 18.00		DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00
+	Hs
		986022 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11
+	Mm
		956523 Q91YX7_MOUSE (103-289): 1.77e-16: 86.7: 18.00		DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51
+	Rn
		724630 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		IRS1_RAT (4-375): 5.81e-91: 300: 16.24
+	Hs
		724535 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		IRS1_HUMAN (4-375): 4.22e-89: 294: 16.03
+	Hs
		986064 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		IRS2_HUMAN (15-348): 2.09e-75: 257: 16.89
+	Rn
		94387 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		F1MAL5_RAT (15-348): 1.6e-74: 254: 15.68
+	Rn
		724631 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		IRS1_RAT (4-375): 5.81e-91: 300: 16.24
+	Hs
		151763 GRB2_HUMAN (172-308): 8.6e-11: 64.7: 30.71		IRS4_HUMAN (4-392): 7.12e-83: 277: 16.01
+	Hs
		985997 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		FRS2_HUMAN (143-403): 8.28e-64: 214: 19.39
+	Rn
		88883 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		D4A244_RAT (143-403): 9.44e-63: 212: 19.73
+	Mm
		719314 PTN11_MOUSE (159-338): 5.59e-25: 113: 24.63		FRS2_MOUSE (143-403): 2.91e-62: 210: 19.39
+	Rn
		94388 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		F1MAL5_RAT (15-348): 1.6e-74: 254: 15.68
+	Hs
		207310 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		FRS3_HUMAN (143-359): 1.66e-47: 171: 23.87
+	Rn
		88884 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		D4A244_RAT (143-403): 9.44e-63: 212: 19.73
+	Hs
		986000 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		GAB3_HUMAN (17-133): 2.76e-09: 61.1: 16.53