Protein: NMDE2
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)

Gene: NMDE2, GRIN2B
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q13224

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004972 - NMDA glutamate receptor activity
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051658

NMDZ1
Glutamate receptor ionotropic, NMDA 1

10

20

Small-scale

0.969

High

1088763

NMDE1
Glutamate receptor ionotropic, NMDA 2A

4

18

Small-scale

0.890

High

1006059

DLG4
Disks large homolog 4

22

20

Small-scale

0.767

High

1098539

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

9

16

Small-scale

0.757

High

1098529

DLG3
Disks large homolog 3

6

20

Small-scale

0.729

High

1091487

DLG1
Disks large homolog 1

6

20

Small-scale

0.721

High

1098522

DLG2
Disks large homolog 2

3

20

Small-scale

0.648

High

1098516

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

18

Small-scale

0.647

High

1098525

NMD3A
Glutamate receptor ionotropic, NMDA 3A

1

18

Small-scale

0.618

High

1098526

NETO1
Neuropilin and tolloid-like protein 1

1

8

Small-scale

0.618

High

440532

FYN
Tyrosine-protein kinase Fyn

2

12

Small-scale

0.602

High

1098518

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

2

16

Small-scale

0.595

High

422039

A4
Amyloid-beta precursor protein

2

10

Small-scale

0.584

High

363218

EGFR
Epidermal growth factor receptor

1

9

Small-scale

0.578

High

67664

RHG32
Rho GTPase-activating protein 32

1

1

Small-scale

0.573

High

1098520

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

10

Small-scale

0.573

High

1098531

MIB2
E3 ubiquitin-protein ligase MIB2

1

4

Small-scale

0.561

High

1098536

LIN7B
Protein lin-7 homolog B

1

20

Small-scale

0.561

High

1098519

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

14

Small-scale

0.550

High

167695

LIN7A
Protein lin-7 homolog A

1

20

Small-scale

0.501

High

603261

KPCA
Protein kinase C alpha type

1

13

Small-scale

0.501

High

995014

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.501

High

997679

CSK21
Casein kinase II subunit alpha

1

6

Small-scale

0.501

High

1098521

SCRIB
Protein scribble homolog

1

20

High-throughput

0.501

High

1098533

ERBIN
Erbin

1

4

Small-scale

0.501

High

1098538

EXOC7
Exocyst complex component 7

1

3

Small-scale

0.501

High

1098524

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

20

Small-scale

0.494

High

773735

ACTN2
Alpha-actinin-2

1

9

Small-scale

0.481

High

1098532

AP2M1
AP-2 complex subunit mu

1

7

Small-scale

0.481

High

1098535

AP1M1
AP-1 complex subunit mu-1

1

7

Small-scale

0.481

High

165938

FFAR1
Free fatty acid receptor 1

1

11

Small-scale

0.479

High

241573

PRKN
E3 ubiquitin-protein ligase parkin

1

5

Small-scale

0.479

High

245621

ZEB2
Zinc finger E-box-binding homeobox 2

1

1

High-throughput

0.479

High

472054

MET
Hepatocyte growth factor receptor

1

8

Small-scale

0.479

High

557276

SRC
Proto-oncogene tyrosine-protein kinase Src

1

12

Small-scale

0.479

High

652505

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

Small-scale

0.479

High

710825

EPHB2
Ephrin type-B receptor 2

1

3

Small-scale

0.479

High

791357

SYUA
Alpha-synuclein

1

1

Small-scale

0.479

High

845020

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

907312

APLP1
Amyloid beta precursor like protein 1

1

9

Small-scale

0.479

High

1051917

KPCD
Protein kinase C delta type

1

13

Small-scale

0.479

High

1055306

APLP2
Amyloid beta precursor like protein 2

1

9

Small-scale

0.479

High

1098523

DPYL2
Dihydropyrimidinase-related protein 2

1

7

Small-scale

0.479

High

1098528

RYR2
Ryanodine receptor 2

1

5

Small-scale

0.479

High

1098530

EXOC4
Exocyst complex component 4

1

4

Small-scale

0.479

High

1098534

SGMR1
Sigma non-opioid intracellular receptor 1

1

2

Small-scale

0.479

High

992726

RACK1
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.458

High

1008612

MAP1A
Microtubule-associated protein 1A

1

0

Small-scale

0.458

High

1039191

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

1098537

KDM5B
Lysine-specific demethylase 5B

1

0

Small-scale

0.458

High

625350

CSK22
Casein kinase II subunit alpha'

1

5

Small-scale

0.457

High

471741

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

9

High-throughput

0.445

High

658821

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

8

High-throughput

0.445

High

659020

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

9

High-throughput

0.445

High

1050785

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

13

High-throughput

0.445

High

1090054

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

9

High-throughput

0.445

High

1098517

NDK3
Nucleoside diphosphate kinase 3

1

2

High-throughput

0.445

High

125837

AP4M1
AP-4 complex subunit mu-1

1

7

Small-scale

0.439

High

105861

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

107333

F8VWT9
HECT domain E3 ubiquitin protein ligase 4

1

9

Small-scale

0.437

High

252860

EXOC3
Exocyst complex component 3

1

2

Small-scale

0.437

High

1098527

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

8

High-throughput

0.437

High

1098540

NGN3
Neurogenin-3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025