HitPredict

Interactor 1: DCEA (P69908)
Glutamate decarboxylase alpha (GAD-alpha) (EC 4.1.1.15)
Gene: gadA

Interactor 2: DCEB (P69910)
Glutamate decarboxylase beta (GAD-beta) (EC 4.1.1.15)
Gene: gadB

Species: Escherichia coli K-12

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16606699, 15690043
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pyridoxal_deC~Pyridoxal_deC
Common GO terms	GO:0004351 - glutamate decarboxylase activity GO:0005829 - cytosol GO:0006538 - glutamate catabolic process GO:0016020 - membrane GO:0030170 - pyridoxal phosphate binding and 1 others more... GO:0051454 - intracellular pH elevation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 466 Ec			1 466
+	Ec
		936104 DCEA_ECOLI (1-466): 4.49e-173: 495: 100.00		DCEA_ECOLI (1-466): 4.49e-173: 495: 98.93
+	Ec
		936106 DCEB_ECOLI (1-466): 7.25e-173: 495: 98.93		DCEB_ECOLI (1-466): 7.25e-173: 495: 100.00
+	At
		1114886 DCE1_ARATH (8-453): 2.19e-150: 439: 44.07		DCE1_ARATH (8-453): 2.19e-150: 439: 44.07
+	Hs
		983535 DCE2_HUMAN (8-448): 3.12e-145: 429: 15.29		DCE2_HUMAN (8-448): 3.12e-145: 429: 15.29
+	Hs
		983562 DCE2_HUMAN (8-448): 3.12e-145: 429: 15.29		DCE1_HUMAN (4-448): 9.26e-140: 415: 12.82
+	Rn
		574786 DCE2_RAT (8-448): 1.47e-144: 427: 15.29		DCE1_RAT (4-448): 9.48e-140: 415: 13.03
+	Hs
		1303370 DCE1_HUMAN (4-448): 9.26e-140: 415: 12.82		DCE1_HUMAN (4-448): 9.26e-140: 415: 12.82
+	Rn
		574785 DCE1_RAT (4-448): 9.48e-140: 415: 13.03		DCE1_RAT (4-448): 9.48e-140: 415: 13.03
+	Hs
		595515 DDC_HUMAN (1-449): 3.44e-140: 412: 15.04		DDC_HUMAN (1-449): 3.44e-140: 412: 15.04
+	Ce
		109452 H2KYG4_CAEEL (1-448): 5.05e-116: 352: 12.88		H2KYG4_CAEEL (1-448): 5.05e-116: 352: 12.69
+	Ce
		219909 O45137_CAEEL (1-448): 1.48e-114: 348: 12.66		O45137_CAEEL (1-448): 1.48e-114: 348: 12.48
+	Sc
		981199 DCE_YEAST (7-450): 6.53e-112: 343: 35.89		DCE_YEAST (7-450): 6.53e-112: 343: 36.09
+	At
		1247643 PAAS_ARATH (1-451): 5.43e-110: 335: 14.55		PAAS_ARATH (1-451): 5.43e-110: 335: 14.55
+	Sc
		984231 SGPL_YEAST (3-459): 2.06e-108: 334: 17.27		SGPL_YEAST (3-459): 2.06e-108: 334: 17.70
+	Hs
		1159615 PDXD1_HUMAN (4-380): 9.52e-64: 221: 10.28		PDXD2_HUMAN (4-380): 3.49e-65: 218: 11.00