Interactor 1: HEM (P55162)
Membrane-associated protein Hem (dHem-2)
Gene: HEM

Interactor 2: CYFIP (Q9VF87)
Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1)
Gene: CYFIP

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.916

The method score is based on:

Property Details
Experiments 22010197, 15385157, 15269173, 22036573, 38944040
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CYRIA-B_Rac1-bd~Nckap1, FragX_IP~Nckap1
Common GO terms GO:0000902 - cell morphogenesis
GO:0008360 - regulation of cell shape
GO:0030031 - cell projection assembly
GO:0030866 - cortical actin cytoskeleton organization
GO:0031209 - SCAR complex
and 3 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 1126
Dm

1 1291
+ Mm
+ Hs
+ Hs
+ Mm
+ Ce
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025