Protein: NCKP1
Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)

Gene: NCKP1, NCKAP1
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9Y2A7

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0001701 - in utero embryonic development
GO:0001726 - ruffle
GO:0001756 - somitogenesis
GO:0001843 - neural tube closure

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316726

ABI1
Abl interactor 1

8

8

Small-scale

0.974

High

1272227

CYFP1
Cytoplasmic FMR1-interacting protein 1

10

6

Small-scale

0.973

High

1390228

CYFP2
Cytoplasmic FMR1-interacting protein 2

5

6

Small-scale

0.919

High

1452530

ABI2
Abl interactor 2

4

9

High-throughput

0.903

High

967040

1433G
14-3-3 protein gamma

5

5

High-throughput

0.716

High

730369

1433B
14-3-3 protein beta/alpha

5

5

High-throughput

0.716

High

1364474

WASF1
Actin-binding protein WASF1

5

7

Small-scale

0.714

High

1462705

BAIP2
BAR/IMD domain-containing adapter protein 2

4

3

High-throughput

0.699

High

1049921

1433F
14-3-3 protein eta

4

5

High-throughput

0.697

High

1490663

WASF2
Actin-binding protein WASF2

4

7

Small-scale

0.696

High

988837

RAC1
Ras-related C3 botulinum toxin substrate 1

4

4

Small-scale

0.696

High

222228

NCK2
Cytoplasmic protein NCK2

4

3

High-throughput

0.691

High

1357233

BRK1
Protein BRICK1

4

2

Small-scale

0.687

High

1462632

WASF3
Actin-binding protein WASF3

3

7

High-throughput

0.675

High

1389817

DTBP1
Dysbindin

3

0

High-throughput

0.638

High

1410930

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

1247758

NHS
Actin remodeling regulator NHS

2

2

High-throughput

0.628

High

1449329

HOME3
Homer protein homolog 3

2

5

High-throughput

0.628

High

990888

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.621

High

362416

ABL1
Tyrosine-protein kinase ABL1

2

2

High-throughput

0.611

High

487897

PARP1
Poly [ADP-ribose] polymerase 1

2

1

High-throughput

0.611

High

840994

ABL2
Tyrosine-protein kinase ABL2

2

2

High-throughput

0.611

High

176579

GRRE1
Granule associated Rac and RHOG effector protein 1

2

0

High-throughput

0.602

High

1461778

CBLC
E3 ubiquitin-protein ligase CBL-C

2

0

High-throughput

0.602

High

594145

NCK1
SH2/SH3 adapter protein NCK1

2

5

High-throughput

0.601

High

1352140

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

2

3

High-throughput

0.601

High

1211766

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.585

High

243328

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

1490664

MYO16
Unconventional myosin-XVI

1

1

Small-scale

0.578

High

1454445

ABI3
ABI gene family member 3

1

9

High-throughput

0.575

High

1211410

NHSL1
NHS-like protein 1

2

2

High-throughput

0.574

High

397260

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1256818

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

5

Small-scale

0.561

High

1454240

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

5

Small-scale

0.561

High

502180

H2AZ
Histone H2A.Z

1

1

High-throughput

0.536

High

535690

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

691555

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

953198

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.536

High

988046

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.536

High

993391

ACTG
Actin, cytoplasmic 2

1

5

High-throughput

0.536

High

1144329

STK38
Serine/threonine-protein kinase 38

1

1

High-throughput

0.536

High

1311229

RHG12
Rho GTPase-activating protein 12

1

1

High-throughput

0.536

High

1384973

SGK3
Serine/threonine-protein kinase Sgk3

1

1

High-throughput

0.536

High

1391872

AURKB
Aurora kinase B

1

1

High-throughput

0.536

High

1431485

CAD23
Cadherin-23

1

1

High-throughput

0.536

High

258397

GAS7
Growth arrest-specific protein 7

1

2

High-throughput

0.527

High

291880

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

447595

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

574003

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.513

High

972151

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

994424

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

1136622

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

1232744

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

1347901

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1379971

LHX4
LIM/homeobox protein Lhx4

1

0

High-throughput

0.513

High

1395046

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1450663

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.513

High

1490660

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

0

High-throughput

0.513

High

1135514

T132D
Transmembrane protein 132D

1

1

Small-scale

0.504

High

1205215

NHSL2
NHS-like protein 2

2

2

High-throughput

0.504

High

1369648

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

182842

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

1383798

TTC28
Tetratricopeptide repeat protein 28

1

1

High-throughput

0.489

High

1490662

KC1G3
Casein kinase I isoform gamma-3

1

1

High-throughput

0.489

High

126880

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.479

High

132391

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

364053

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

541767

FGFR1
Fibroblast growth factor receptor 1

1

4

High-throughput

0.479

High

581378

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

583031

EZRI
Ezrin

1

2

High-throughput

0.479

High

710919

EPHB2
Ephrin type-B receptor 2

1

2

High-throughput

0.479

High

731715

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

932157

EPHA4
Ephrin type-A receptor 4

1

2

High-throughput

0.479

High

953766

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.479

High

962644

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

995909

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.479

High

1280619

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1295231

HOME1
Homer protein homolog 1

1

5

High-throughput

0.479

High

1331380

ENAH
Protein enabled homolog

1

5

High-throughput

0.479

High

1350507

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1391218

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

1438251

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.479

High

1462003

ALK
ALK tyrosine kinase receptor

1

4

High-throughput

0.479

High

522308

OSTP
Osteopontin

1

0

Small-scale

0.460

High

320801

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

324239

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

346524

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

376115

RASK
GTPase KRas

1

0

High-throughput

0.458

High

538142

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

540762

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

646964

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

696904

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

831675

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

927179

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

946913

H2B1D
Histone H2B type 1-D

1

0

High-throughput

0.458

High

971311

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1045930

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1107352

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1115159

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1138775

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1194468

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1231746

NXN
Nucleoredoxin

1

0

High-throughput

0.458

High

1238511

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1251282

DNMBP
Dynamin-binding protein

1

0

Small-scale

0.458

High

1256155

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1310818

CUL9
Cullin-9

1

0

High-throughput

0.458

High

1324115

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1338444

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1360849

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1363898

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1364713

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1370478

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1380692

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1429892

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1451326

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1453057

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1458557

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

1459360

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

530616

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

896670

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.445

High

1110595

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

412838

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

761313

RYK
Tyrosine-protein kinase RYK

1

2

Small-scale

0.437

High

1034383

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

4

High-throughput

0.437

High

1147467

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.437

High

1367625

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1434268

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1209811

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1292311

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1353000

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

1400199

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

1407403

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.426

High

1445849

S40A1
Ferroportin

1

0

High-throughput

0.426

High

361

A0A075B6E5
ENAH actin regulator

1

4

High-throughput

0.407

High

1295187

Q86YM6
HOMER1F

1

2

High-throughput

0.407

High

1428271

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

1

High-throughput

0.407

High

1332974

ZN511
Zinc finger protein 511

4

0

High-throughput

0.360

High

1192214

AMZ1
Archaemetzincin-1

2

0

High-throughput

0.328

High

1436415

PAAT
ATPase PAAT

2

0

High-throughput

0.328

High

1454204

NHSL3
NHS-like protein 3

2

0

High-throughput

0.328

High

1238073

CGB2
Choriogonadotropin subunit beta variant 2

2

0

High-throughput

0.288

High

567114

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

943667

SIK1
Serine/threonine-protein kinase SIK1

1

0

High-throughput

0.279

Low

1153703

MPPD2
Metallophosphoesterase MPPED2

1

0

High-throughput

0.279

Low

1192146

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.279

Low

1235084

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

0

High-throughput

0.279

Low

1244091

CXB7
Gap junction beta-7 protein

1

0

High-throughput

0.279

Low

1258714

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

1363656

H1X
Histone H1.10

1

0

High-throughput

0.279

Low

1389711

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.279

Low

1403990

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.279

Low

1414999

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

0

High-throughput

0.279

Low

1490661

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

106878

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

373537

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

418521

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

587261

ITF2
Transcription factor 4

1

0

High-throughput

0.249

Low

590069

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

643150

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

769552

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965346

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1005259

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1100556

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1155923

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1249344

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256641

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

1276991

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1293215

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1438952

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1448250

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

1454520

PCD10
Protocadherin-10

1

0

Small-scale

0.249

Low

1460584

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.249

Low

62619

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

108008

SO1B7
Putative solute carrier organic anion transporter family member 1B7

1

0

High-throughput

0.232

Low

638557

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.232

Low

1235276

NCLX
Mitochondrial sodium/calcium exchanger protein

1

0

High-throughput

0.232

Low

1288175

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

1336048

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.232

Low

1392601

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025