Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: TLR4 (Q9QUK6)
Toll-like receptor 4 (CD antigen CD284)
Gene: TLR4

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.650

The method score is based on:

Property Details
Experiments 19898473, 23962979, 21911421
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0007254 - JNK cascade
GO:0031663 - lipopolysaccharide-mediated signaling pathway
GO:0032735 - positive regulation of interleukin-12 production
GO:0032755 - positive regulation of interleukin-6 production
GO:0034142 - toll-like receptor 4 signaling pathway
and 7 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 530
Mm

1 835
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024