HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	25416956, 11504882, 33961781, 36931259, 15324660, 27684187, 31040226, 23752268, 17159145, 17353931, 28514442, 18045992
Identification Methods	two hybrid, pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Hs			1 247
+	Hs
		940896 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		940926 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		729707 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		940908 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		690861 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		730470 HDAC4_HUMAN (1-1072): 0: 973: 100.00		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Mm
		1240165 HDAC4_MOUSE (1-1072): 0: 940: 93.66		1433B_MOUSE (2-247): 8.61e-109: 315: 75.81
+	Hs
		972117 HDAC9_HUMAN (25-1025): 0: 798: 56.25		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		972146 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Mm
		972214 Q3UJF1_MOUSE (2-1084): 0: 782: 55.84		1433E_MOUSE (1-244): 2.03e-141: 398: 63.53
+	Hs
		967035 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		1049920 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		990854 HDAC9_HUMAN (25-1025): 0: 798: 56.25		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		730364 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		990882 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		691548 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Mm
		996609 Q3UJF1_MOUSE (2-1084): 0: 782: 55.84		1433T_MOUSE (2-245): 3.01e-105: 306: 70.73
+	Hs
		730950 HDAC9_HUMAN (25-1025): 0: 798: 56.25		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		730968 HDAC5_HUMAN (1-1084): 0: 784: 55.67		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Mm
		267035 Q3UJF1_MOUSE (2-1084): 0: 782: 55.84		1433S_MOUSE (2-236): 1.39e-95: 281: 65.96