HitPredict

Interactor 1: D5SHR3 (D5SHR3)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Gene: Hecw

Interactor 2: RL40 (P18101)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: RpL40

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 434 Dm			1 128
+	Hs
		987478 SMUF2_HUMAN (18-434): 0: 533: 40.45		RL40_HUMAN (1-128): 6.64e-60: 182: 97.66
+	Sp
		153855 PUB3_SCHPO (13-434): 0: 538: 46.57		RL402_SCHPO (1-128): 5.15e-57: 174: 92.19
+	Hs
		987397 HUWE1_HUMAN (13-433): 5.07e-168: 525: 36.71		RL40_HUMAN (1-128): 6.64e-60: 182: 97.66
+	Hs
		131925 WWP2_HUMAN (18-434): 0: 560: 44.76		RS27A_HUMAN (1-88): 1.82e-38: 128: 86.36
+	Dm
		1489825 Q9W325_DROME (15-434): 0: 542: 100.00		Q9W418_DROME (1-77): 1.31e-41: 145: 98.70
+	Hs
		507111 NEDD4_HUMAN (17-432): 0: 566: 45.93		UBB_HUMAN (1-76): 1.61e-33: 118: 100.00
+	Hs
		507318 ITCH_HUMAN (18-434): 0: 562: 46.21		UBB_HUMAN (1-76): 1.61e-33: 118: 100.00
+	Rn
		1221048 Q5YB86_RAT (18-434): 0: 560: 46.21		UBC_RAT (1-102): 9.87e-32: 119: 77.45
+	Hs
		131689 WWP2_HUMAN (18-434): 0: 560: 44.76		UBB_HUMAN (1-76): 1.61e-33: 118: 100.00
+	Hs
		987205 WWP1_HUMAN (18-434): 0: 550: 44.79		RS27A_HUMAN (1-88): 1.82e-38: 128: 86.36
+	Mm
		987293 HUWE1_MOUSE (13-433): 5.07e-168: 525: 36.71		RS27A_MOUSE (1-88): 2.1e-38: 128: 86.36
+	Hs
		507377 SMUF2_HUMAN (18-434): 0: 533: 40.45		UBB_HUMAN (1-76): 1.61e-33: 118: 100.00
+	At
		1167700 UPL1_ARATH (6-432): 1.82e-169: 529: 38.07		UBQ3_ARATH (1-77): 3.83e-33: 119: 94.81
+	Mm
		509127 HUWE1_MOUSE (13-433): 5.07e-168: 525: 36.71		UBC_MOUSE (1-102): 1.11e-31: 119: 77.45
+	Hs
		507253 HUWE1_HUMAN (13-433): 5.07e-168: 525: 36.71		UBB_HUMAN (1-76): 1.61e-33: 118: 100.00
+	At
		1167704 UPL2_ARATH (6-432): 3.37e-167: 522: 37.62		UBQ3_ARATH (1-77): 3.83e-33: 119: 94.81