HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	35271311, 33961781, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 688 Hs			1 551
+	Hs
		1084581 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		942799 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		942631 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		833888 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		516460 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516651 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		942911 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		978568 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		PRB3_HUMAN (145-375): 1.97e-10: 64.6: 22.18
+	Hs
		270386 KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		516362 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		833924 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		834033 CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516416 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516417 CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Dm
		631326 Q9VR61_DROME (69-348): 1.39e-36: 149: 15.39		BRM_DROME (249-551): 1.19e-45: 175: 20.72
+	Dm
		1372933 Q9VR61_DROME (69-348): 1.39e-36: 149: 15.39		CPSF6_DROME (8-485): 1.09e-43: 166: 36.97
+	Hs
		833971 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		833716 CLK1_HUMAN (52-226): 1.37e-61: 215: 31.25		PRB3_HUMAN (145-375): 1.97e-10: 64.6: 22.18
+	Hs
		1319415 DYRK4_HUMAN (2-222): 1.98e-60: 213: 26.09		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Dm
		834210 DOA_DROME (519-687): 7.73e-14: 77: 29.12		CPSF6_DROME (8-485): 1.09e-43: 166: 36.97