HitPredict

Interactor 1: FUS (P56959)
RNA-binding protein FUS (Protein pigpen)
Gene: FUS

Interactor 2: SRSF2 (Q62093)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	9774382
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms	GO:0005634 - nucleus GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Mm			1 221
+	Hs
		775106 FUS_HUMAN (1-518): 1.14e-35: 141: 84.82		SF3B4_HUMAN (4-205): 3.92e-52: 175: 17.24
+	Hs
		1032987 EWS_HUMAN (3-444): 5.4e-30: 125: 34.13		SF3B4_HUMAN (4-205): 3.92e-52: 175: 17.24
+	Mm
		1223524 HTSF1_MOUSE (156-365): 5.77e-36: 144: 13.33		SRSF2_MOUSE (1-221): 1.23e-43: 147: 100.00
+	Hs
		1029453 EWS_HUMAN (3-444): 5.4e-30: 125: 34.13		SRSF2_HUMAN (1-221): 1.23e-43: 147: 100.00
+	Hs
		1102042 RBP56_HUMAN (3-447): 8.83e-40: 154: 45.41		PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37
+	Hs
		319099 SC24D_HUMAN (21-292): 6.91e-14: 76.6: 14.61		SF3B4_HUMAN (4-205): 3.92e-52: 175: 17.24
+	Mm
		953827 Q8BQ46_MOUSE (3-447): 4.23e-38: 148: 45.41		CIRBP_MOUSE (11-173): 3.39e-25: 98.8: 34.15
+	Hs
		775060 FUS_HUMAN (1-518): 1.14e-35: 141: 84.82		PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37
+	Mm
		915302 EWS_MOUSE (3-444): 1.94e-42: 162: 35.31		TIA1_MOUSE (7-184): 4.43e-16: 77.7: 11.67
+	Hs
		1033296 EWS_HUMAN (3-444): 5.4e-30: 125: 34.13		PUF60_HUMAN (8-108): 8.36e-24: 100: 23.76
+	Hs
		550392 RBP56_HUMAN (3-447): 8.83e-40: 154: 45.41		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89
+	Hs
		1090216 PABP4_HUMAN (274-372): 4.99e-13: 73.6: 22.22		ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79
+	Hs
		550147 FUS_HUMAN (1-518): 1.14e-35: 141: 84.82		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89
+	Hs
		726754 EWS_HUMAN (3-444): 5.4e-30: 125: 34.13		TIA1_HUMAN (9-182): 8.58e-16: 76.9: 10.73
+	Hs
		1102145 RBM8A_HUMAN (238-359): 1.46e-23: 99.2: 29.51		PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37
+	Hs
		1032961 EWS_HUMAN (3-444): 5.4e-30: 125: 34.13		ELAV3_HUMAN (115-195): 2.56e-11: 63.8: 11.11
+	Hs
		506129 PABP4_HUMAN (274-372): 4.99e-13: 73.6: 22.22		PAB4L_HUMAN (15-92): 8.6e-21: 90.9: 26.92
+	Hs
		550546 RBM8A_HUMAN (238-359): 1.46e-23: 99.2: 29.51		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89
+	Hs
		1102056 PABP4_HUMAN (274-372): 4.99e-13: 73.6: 22.22		PABP5_HUMAN (16-95): 2.24e-18: 84.4: 21.25
+	Hs
		550262 PABP4_HUMAN (274-372): 4.99e-13: 73.6: 22.22		PABP1_HUMAN (104-194): 9.81e-11: 62.7: 9.89