HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0032212 - positive regulation of telomere maintenance via telomerase GO:0051973 - positive regulation of telomerase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 344
+	Hs
		681999 TCPH_HUMAN (4-532): 0: 591: 34.08		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		681786 TCPB_HUMAN (1-535): 0: 586: 100.00		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		1292186 TCPH_HUMAN (4-532): 0: 591: 34.08		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		609692 TCPH_HUMAN (4-532): 0: 591: 34.08		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		568623 TCPB_HUMAN (1-535): 0: 586: 100.00		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		609660 TCPB_HUMAN (1-535): 0: 586: 100.00		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Dm
		1213438 Q9W392_DROME (4-535): 0: 568: 70.73		AKT1_DROME (3-343): 2.15e-133: 394: 28.01
+	Hs
		681738 TCPG_HUMAN (3-532): 0: 561: 28.33		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		826819 TCPG_HUMAN (3-532): 0: 561: 28.33		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Dm
		1213398 Q9VHL2_DROME (5-525): 0: 554: 31.75		AKT1_DROME (3-343): 2.15e-133: 394: 28.01
+	Hs
		609652 TCPG_HUMAN (3-532): 0: 561: 28.33		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		573141 TCPA_HUMAN (5-533): 0: 541: 34.30		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		681735 TCPE_HUMAN (1-528): 0: 541: 32.29		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		573416 TCPA_HUMAN (5-533): 0: 541: 34.30		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		568585 TCPE_HUMAN (1-528): 0: 541: 32.29		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		573129 TCPA_HUMAN (5-533): 0: 541: 34.30		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		609651 TCPE_HUMAN (1-528): 0: 541: 32.29		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		128992 TCPB_HUMAN (1-535): 0: 586: 100.00		PLK4_HUMAN (74-331): 4.48e-53: 189: 36.78
+	Dm
		520038 TCPA_DROME (1-528): 7.49e-82: 267: 34.55		AKT1_DROME (3-343): 2.15e-133: 394: 28.01