HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ank_4~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 193
+	Hs
		962478 Q9H4D1_HUMAN (1-832): 0: 708: 92.31		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		988289 ANK2_HUMAN (592-832): 3.09e-65: 240: 27.89		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		962626 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		988816 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		466521 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71
+	Hs
		1015901 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40
+	Hs
		955746 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		581370 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RAC2_HUMAN (1-193): 2.82e-75: 226: 53.61
+	Hs
		953754 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RAC3_HUMAN (1-179): 3.87e-73: 220: 57.54
+	Hs
		978398 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RHOB_HUMAN (1-191): 9.8e-73: 219: 83.94
+	Hs
		126869 KDIS_HUMAN (597-832): 8.45e-63: 232: 27.43		RHOD_HUMAN (7-182): 1.69e-69: 212: 53.98
+	Hs
		961998 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		988324 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		1015396 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40
+	Hs
		955105 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		977967 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		RHOB_HUMAN (1-191): 9.8e-73: 219: 83.94
+	Hs
		126571 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		RHOD_HUMAN (7-182): 1.69e-69: 212: 53.98