HitPredict

Interactor 1: CCL7 (P80098)
C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene: CCL7

Interactor 2: ACKR4 (Q9NPB9)
Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Gene: ACKR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10734104
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 350
+	Hs
		1305163 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		ACKR4_HUMAN (1-350): 4.66e-89: 272: 100.00
+	Hs
		849619 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		561732 CL3L1_HUMAN (1-94): 5.46e-36: 119: 36.17		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		849614 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		134400 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134356 CCL4_HUMAN (1-93): 5.91e-35: 116: 37.63		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134374 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		783833 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Hs
		830629 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CXCR3_HUMAN (2-349): 7.54e-71: 227: 29.63
+	Hs
		849654 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Mm
		500590 CCL3_MOUSE (1-94): 3.69e-35: 117: 37.23		CCR1_MOUSE (10-349): 4.08e-73: 232: 30.64
+	Mm
		486358 CCL2_MOUSE (1-94): 2.82e-36: 121: 53.19		CCR2_MOUSE (1-349): 7.53e-71: 227: 28.69
+	Hs
		783816 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Hs
		561733 CL3L1_HUMAN (1-94): 5.46e-36: 119: 36.17		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Mm
		500591 CCL3_MOUSE (1-94): 3.69e-35: 117: 37.23		CCR3_MOUSE (30-348): 1.44e-71: 228: 31.39
+	Hs
		561728 CL3L1_HUMAN (1-94): 5.46e-36: 119: 36.17		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		830622 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		CXCR3_HUMAN (2-349): 7.54e-71: 227: 29.63
+	Hs
		849648 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		686636 CCL7_HUMAN (17-99): 7.82e-35: 116: 100.00		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Mm
		139696 CCL2_MOUSE (1-94): 2.82e-36: 121: 53.19		ACKR2_MOUSE (22-314): 1.65e-39: 145: 31.37