HitPredict - High confidence protein-protein interactions

Interactor 1: RIPK2 (P58801)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (Receptor-interacting protein 2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Interactor 2: NOD2 (Q8K3Z0)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15)
Gene: NOD2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18775659
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0002250 - adaptive immune response GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton and 26 others more... GO:0005886 - plasma membrane GO:0007249 - canonical NF-kappaB signal transduction GO:0007254 - JNK cascade GO:0031982 - vesicle GO:0032731 - positive regulation of interleukin-1 beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0032874 - positive regulation of stress-activated MAPK cascade GO:0032991 - protein-containing complex GO:0034134 - toll-like receptor 2 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043330 - response to exogenous dsRNA GO:0045087 - innate immune response GO:0046330 - positive regulation of JNK cascade GO:0050700 - CARD domain binding GO:0050830 - defense response to Gram-positive bacterium GO:0051403 - stress-activated MAPK cascade GO:0060907 - positive regulation of macrophage cytokine production GO:0070371 - ERK1 and ERK2 cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0071222 - cellular response to lipopolysaccharide GO:0071224 - cellular response to peptidoglycan GO:0071225 - cellular response to muramyl dipeptide GO:0098792 - xenophagy GO:1904417 - positive regulation of xenophagy
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1	539
Mm

1	1020

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Last updated: 11Aug2025