HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 39358380
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 1025
+	Hs
		1234828 POTEE_HUMAN (1-375): 0: 736: 92.00		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		772838 ACTBL_HUMAN (2-375): 0: 735: 91.71		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		953160 ACTB_HUMAN (1-375): 0: 603: 100.00		SWP70_HUMAN (370-824): 7.3e-58: 212: 19.22
+	Hs
		993257 ACTG_HUMAN (1-375): 0: 601: 98.93		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		1143145 ACTBL_HUMAN (2-375): 0: 735: 91.71		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		993216 ACTG_HUMAN (1-375): 0: 601: 98.93		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		995647 ACTC_HUMAN (2-375): 0: 592: 94.12		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		773154 ACTC_HUMAN (2-375): 0: 592: 94.12		MYH10_HUMAN (242-1024): 1.66e-21: 103: 8.45
+	Mm
		953280 ACTB_MOUSE (1-375): 0: 603: 100.00		MYH9_MOUSE (561-1013): 2.5e-17: 90.2: 12.80
+	Hs
		772705 ACTB_HUMAN (1-375): 0: 603: 100.00		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		772729 ACTG_HUMAN (1-375): 0: 601: 98.93		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Rn
		953311 ACTB_RAT (1-375): 0: 603: 100.00		MYH10_RAT (540-1024): 2.28e-15: 83.6: 10.20
+	Hs
		772733 ACTC_HUMAN (2-375): 0: 592: 94.12		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		772734 ACTS_HUMAN (2-375): 0: 592: 93.58		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		952834 ACTB_HUMAN (1-375): 0: 603: 100.00		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		993183 ACTG_HUMAN (1-375): 0: 601: 98.93		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Rn
		953303 ACTB_RAT (1-375): 0: 603: 100.00		MYH9_RAT (682-1024): 3.03e-10: 66.7: 12.50
+	Hs
		271689 ACTB_HUMAN (1-375): 0: 603: 100.00		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Hs
		995607 ACTC_HUMAN (2-375): 0: 592: 94.12		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		996459 ACTS_HUMAN (2-375): 0: 592: 93.58		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96