HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	30021884, 35575683
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 4684
+	Hs
		996459 ACTS_HUMAN (1-377): 0: 599: 98.94		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		952834 ACTB_HUMAN (4-377): 0: 598: 94.12		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		993183 ACTG_HUMAN (4-377): 0: 598: 94.39		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		977703 ACTA_HUMAN (1-377): 0: 597: 98.41		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		993422 ACTH_HUMAN (4-377): 0: 591: 98.93		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Mm
		993452 ACTH_MOUSE (4-377): 0: 591: 98.93		PLEC_MOUSE (1-4684): 0: 1757: 93.27
+	Dm
		387027 ACT4_DROME (1-377): 0: 649: 92.57		ACTN_DROME (156-894): 5.82e-121: 410: 23.24
+	Dm
		534344 ACT5_DROME (1-377): 0: 597: 93.10		ACTN_DROME (156-894): 5.82e-121: 410: 23.24
+	Oc
		996588 ACTS_RABIT (1-377): 0: 599: 98.94		Q07931_RABIT (178-398): 2.83e-62: 218: 51.12
+	Hs
		995543 ACTC_HUMAN (1-377): 0: 599: 100.00		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		952750 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		993135 ACTG_HUMAN (4-377): 0: 598: 94.39		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		174729 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTN2_HUMAN (1390-3107): 3.29e-22: 108: 12.11
+	Hs
		540248 ACTB_HUMAN (4-377): 0: 598: 94.12		SPTB1_HUMAN (1903-3210): 1e-21: 107: 10.84
+	Hs
		953184 ACTB_HUMAN (4-377): 0: 598: 94.12		MACF1_HUMAN (4268-4616): 1.6e-15: 87: 19.48
+	Dm
		305328 ACT1_DROME (1-377): 0: 598: 94.43		O77291_DROME (1812-3268): 1.26e-14: 83.9: 9.86
+	Hs
		995549 ACTC_HUMAN (1-377): 0: 599: 100.00		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		996432 ACTS_HUMAN (1-377): 0: 599: 98.94		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		952759 ACTB_HUMAN (4-377): 0: 598: 94.12		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		993139 ACTG_HUMAN (4-377): 0: 598: 94.39		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90