HitPredict

Interactor 1: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0030424 - axon GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4684 Hs			1 376
+	Hs
		952834 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993183 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		993422 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTH_HUMAN (1-376): 0: 589: 87.77
+	Hs
		995607 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		996459 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		977703 PLEC_HUMAN (1-4684): 0: 1793: 100.00		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Mm
		993452 PLEC_MOUSE (1-4684): 0: 1757: 93.27		ACTH_MOUSE (1-376): 0: 589: 87.77
+	Dm
		534344 ACTN_DROME (156-894): 5.82e-121: 410: 23.24		ACT5_DROME (1-376): 0: 597: 89.10
+	Dm
		387027 ACTN_DROME (156-894): 5.82e-121: 410: 23.24		ACT4_DROME (1-376): 0: 589: 89.10
+	Oc
		996588 Q07931_RABIT (178-398): 2.83e-62: 218: 51.12		ACTS_RABIT (2-376): 0: 588: 87.47
+	Hs
		952750 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993135 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		995543 SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		174729 SPTN2_HUMAN (1390-3107): 3.29e-22: 108: 12.11		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		540248 SPTB1_HUMAN (1903-3210): 1e-21: 107: 10.84		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		953184 MACF1_HUMAN (4268-4616): 1.6e-15: 87: 19.48		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Dm
		305328 O77291_DROME (1812-3268): 1.26e-14: 83.9: 9.86		ACT1_DROME (1-376): 0: 597: 90.69
+	Hs
		952759 DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993139 DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		995549 DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90		ACTC_HUMAN (2-376): 0: 589: 88.27