HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043025 - neuronal cell body and 1 others more... GO:0045177 - apical part of cell
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 2671
+	Hs
		1015441 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		962047 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		581049 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		1015442 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		955173 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		955169 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		962050 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		581050 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		962046 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		466253 RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		953449 RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32		ITPR1_HUMAN (2-2663): 0: 3900: 60.67