HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PLCB4 (Q15147)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
Gene: PLCB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 1175
+	Hs
		601297 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		1143122 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		988379 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		1015452 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		962068 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		581061 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		466263 RHOC_HUMAN (5-191): 3.38e-76: 228: 52.41		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		953459 RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32		PLCB4_HUMAN (1-1175): 0: 1171: 100.00
+	Hs
		962115 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		PLCH1_HUMAN (15-990): 0: 817: 25.36
+	Hs
		619023 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PLCG1_HUMAN (559-825): 6.21e-83: 298: 34.91
+	Hs
		619018 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		PLCG1_HUMAN (559-825): 6.21e-83: 298: 34.91
+	Hs
		619071 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		PLCG1_HUMAN (559-825): 6.21e-83: 298: 34.91
+	Hs
		988293 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PLCB3_HUMAN (835-1076): 4.05e-14: 79.7: 13.17
+	Hs
		988285 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PLCB2_HUMAN (821-1082): 5.63e-12: 72.4: 9.77
+	Hs
		580997 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		PLCB3_HUMAN (835-1076): 4.05e-14: 79.7: 13.17