Protein: PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)

Gene: PLCH1
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q4KWH8

Gene Ontology (top 5):
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0016042 - lipid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375572

RASK
GTPase KRas

2

20

High-throughput

0.754

High

1049355

1433F
14-3-3 protein eta

4

6

High-throughput

0.699

High

729890

1433B
14-3-3 protein beta/alpha

4

6

High-throughput

0.691

High

966396

1433G
14-3-3 protein gamma

4

7

High-throughput

0.691

High

990292

1433Z
14-3-3 protein zeta/delta

4

7

High-throughput

0.691

High

691067

1433T
14-3-3 protein theta

3

6

High-throughput

0.650

High

341070

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.618

High

373966

RASN
GTPase NRas

1

20

High-throughput

0.618

High

440099

LCK
Tyrosine-protein kinase Lck

1

17

High-throughput

0.618

High

463555

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.618

High

962115

RHOA
Transforming protein RhoA

1

16

High-throughput

0.618

High

978049

RHOB
Rho-related GTP-binding protein RhoB

1

17

High-throughput

0.618

High

1004076

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

1144932

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.618

High

1195493

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.618

High

971590

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.611

High

1092973

CDC16
Cell division cycle protein 16 homolog

2

0

High-throughput

0.602

High

363371

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.565

High

956322

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.553

High

850777

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

1

High-throughput

0.536

High

1195491

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

1195497

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

428794

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.513

High

859850

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

1195486

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1195495

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1195479

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

1

High-throughput

0.489

High

299223

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

710280

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.479

High

730632

1433S
14-3-3 protein sigma

1

7

High-throughput

0.479

High

764354

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

764805

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

872391

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

936345

AFAD
Afadin

1

4

High-throughput

0.479

High

1159500

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1159673

OCLN
Occludin

1

2

High-throughput

0.479

High

1195483

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.479

High

1195489

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.479

High

604009

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

642907

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

1195481

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1195492

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1195494

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1195484

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.457

High

1195490

MTA3
Metastasis-associated protein MTA3

1

1

Small-scale

0.445

High

890333

NU153
Nuclear pore complex protein Nup153

1

5

High-throughput

0.437

High

1141154

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.437

High

1195482

Q6ICH2
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.437

High

1195485

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1195496

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.437

High

73406

B2CML4
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.407

High

793711

ETFB
Electron transfer flavoprotein subunit beta

2

0

High-throughput

0.328

High

1195480

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1178824

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1195487

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

327286

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

584654

HIS3
Histatin-3

1

0

Small-scale

0.249

Low

1195488

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025