HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	14676191
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0030425 - dendrite GO:0030496 - midbody and 1 others more... GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 752
+	Hs
		601178 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		692132 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		692037 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		692024 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		692041 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		692027 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		580880 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		MARK3_HUMAN (1-752): 0: 695: 59.71
+	Hs
		601344 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		1270523 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		988474 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		1015546 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		955318 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		962195 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		MARK2_HUMAN (2-752): 0: 634: 49.26
+	Hs
		988370 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		MELK_HUMAN (59-752): 4.51e-168: 500: 26.50
+	Hs
		955175 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		MELK_HUMAN (59-752): 4.51e-168: 500: 26.50
+	Hs
		581052 RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75		MELK_HUMAN (59-752): 4.51e-168: 500: 26.50
+	Hs
		1310595 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		BRSK2_HUMAN (55-504): 2.73e-146: 447: 36.66
+	Rn
		930633 RAC1_RAT (1-191): 1.15e-81: 242: 70.31		AAPK1_RAT (40-566): 3.52e-141: 428: 27.26
+	Rn
		930522 RHOA_RAT (5-191): 5.93e-79: 235: 53.48		AAPK1_RAT (40-566): 3.52e-141: 428: 27.26
+	Hs
		955568 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		SIK2_HUMAN (56-367): 5.41e-104: 341: 55.17