HitPredict

Interactor 1: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Interactor 2: RHOJ (Q9H4E5)
Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)
Gene: RHOJ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0030010 - establishment of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 788 Hs			1 214
+	Hs
		988474 MARK2_HUMAN (1-788): 0: 797: 100.00		RAC1_HUMAN (22-214): 5.21e-81: 241: 58.03
+	Hs
		601344 MARK2_HUMAN (1-788): 0: 797: 100.00		RHOQ_HUMAN (17-213): 1.34e-80: 240: 78.00
+	Hs
		978108 MARK2_HUMAN (1-788): 0: 797: 100.00		RHOB_HUMAN (23-214): 1.85e-80: 240: 48.44
+	Hs
		962195 MARK2_HUMAN (1-788): 0: 797: 100.00		RHOA_HUMAN (23-214): 3.34e-78: 234: 47.92
+	Hs
		1015546 MARK2_HUMAN (1-788): 0: 797: 100.00		RHOG_HUMAN (20-214): 6.8e-78: 233: 50.26
+	Hs
		581132 MARK2_HUMAN (1-788): 0: 797: 100.00		RAC2_HUMAN (22-214): 1.82e-77: 232: 57.51
+	Hs
		466323 MARK2_HUMAN (1-788): 0: 797: 100.00		RHOC_HUMAN (23-214): 2.17e-76: 229: 48.44
+	Hs
		953523 MARK2_HUMAN (1-788): 0: 797: 100.00		RAC3_HUMAN (22-195): 2.77e-76: 229: 62.64
+	Hs
		955318 MARK2_HUMAN (1-788): 0: 797: 100.00		CDC42_HUMAN (20-214): 2.17e-76: 229: 61.03
+	Hs
		692132 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOJ_HUMAN (1-214): 6.36e-83: 247: 100.00
+	Hs
		692037 MARK3_HUMAN (3-788): 0: 664: 60.15		RAC1_HUMAN (22-214): 5.21e-81: 241: 58.03
+	Hs
		601178 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOQ_HUMAN (17-213): 1.34e-80: 240: 78.00
+	Hs
		692036 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOB_HUMAN (23-214): 1.85e-80: 240: 48.44
+	Hs
		692027 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOA_HUMAN (23-214): 3.34e-78: 234: 47.92
+	Hs
		692041 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOG_HUMAN (20-214): 6.8e-78: 233: 50.26
+	Hs
		580880 MARK3_HUMAN (3-788): 0: 664: 60.15		RAC2_HUMAN (22-214): 1.82e-77: 232: 57.51
+	Hs
		466114 MARK3_HUMAN (3-788): 0: 664: 60.15		RHOC_HUMAN (23-214): 2.17e-76: 229: 48.44
+	Hs
		692023 MARK3_HUMAN (3-788): 0: 664: 60.15		RAC3_HUMAN (22-195): 2.77e-76: 229: 62.64
+	Hs
		692024 MARK3_HUMAN (3-788): 0: 664: 60.15		CDC42_HUMAN (20-214): 2.17e-76: 229: 61.03
+	Hs
		955482 MARK4_HUMAN (3-788): 0: 574: 48.45		CDC42_HUMAN (20-214): 2.17e-76: 229: 61.03