Interactor 1: DEST (P60981)
Destrin (Actin-depolymerizing factor) (ADF)
Gene: DSTN
Interactor 2: COF2 (Q9Y281)
Cofilin-2 (Cofilin, muscle isoform)
Gene: CFL2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.70 | 1.00 | 0.839 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 31515488, unassigned1304 |
| Identification Methods | two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cofilin_ADF~Cofilin_ADF |
| Common GO terms | GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0030042 - actin filament depolymerization GO:0030043 - actin filament fragmentation GO:0030836 - positive regulation of actin filament depolymerization and 3 others more... |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
