HitPredict

Interactor 1: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	20697350
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 217
+	Hs
		924816 DOK1_HUMAN (1-482): 0: 526: 83.44		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		639441 DOK1_MOUSE (1-482): 0: 545: 100.00		LYN_MOUSE (3-202): 3.06e-38: 140: 27.49
+	Mm
		782845 DOK1_MOUSE (1-482): 0: 545: 100.00		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Mm
		956524 DOK1_MOUSE (1-482): 0: 545: 100.00		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Mm
		337623 DOK1_MOUSE (1-482): 0: 545: 100.00		ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46
+	Hs
		1046417 DOK1_HUMAN (1-482): 0: 526: 83.44		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		557780 DOK1_HUMAN (1-482): 0: 526: 83.44		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337542 DOK1_HUMAN (1-482): 0: 526: 83.44		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789086 DOK1_HUMAN (1-482): 0: 526: 83.44		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Hs
		548746 DOK1_HUMAN (1-482): 0: 526: 83.44		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		433460 DOK1_HUMAN (1-482): 0: 526: 83.44		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		454844 DOK1_HUMAN (1-482): 0: 526: 83.44		FGR_HUMAN (161-215): 5.31e-12: 66.1: 33.33
+	Hs
		442876 DOK1_HUMAN (1-482): 0: 526: 83.44		HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61
+	Hs
		523124 DOK1_HUMAN (1-482): 0: 526: 83.44		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433966 DOK1_HUMAN (1-482): 0: 526: 83.44		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Mm
		1141171 DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30		GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00
+	Hs
		924665 DOK3_HUMAN (1-460): 4.5e-119: 360: 30.85		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		235035 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		337639 DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30		ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46
+	Hs
		235031 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46