HitPredict

Interactor 1: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 32246052, 21455180, 17006537, 29246782, 30017913, 34157307, 34518544, 36192478, 36660824, 36720498, 37431163, 21292167
Identification Methods enzymatic study, pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains E3_UbLigase_RBR~UQ_con, IBR_1~UQ_con
Common GO terms GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0061630 - ubiquitin protein ligase activity
GO:1903955 - positive regulation of protein targeting to mitochondrion
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 147
Hs

1 1072
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025