HitPredict

Interactor 1: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0015031 - protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 1721
+	Mm
		957157 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Hs
		269148 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Mm
		1206702 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Hs
		279856 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		TRIO_HUMAN (154-1590): 1.54e-71: 269: 10.81
+	Mm
		787999 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		EPS15_MOUSE (14-484): 1.37e-37: 156: 16.77
+	Mm
		957141 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		EP15R_MOUSE (183-623): 8.62e-31: 134: 19.46
+	Ce
		283752 CED6_CAEEL (5-428): 1.43e-35: 143: 16.47		VAV_CAEEL (1160-1566): 7.98e-66: 245: 16.74
+	Hs
		787894 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		EPS15_HUMAN (529-913): 1.04e-10: 68.9: 12.69
+	Hs
		557659 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Mm
		788008 NUMB_MOUSE (22-635): 2.06e-45: 175: 13.54		EPS15_MOUSE (14-484): 1.37e-37: 156: 16.77
+	Mm
		1141842 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		EP15R_MOUSE (183-623): 8.62e-31: 134: 19.46
+	Hs
		833668 NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20		EP15R_HUMAN (545-929): 2.95e-11: 70.8: 14.14
+	Hs
		787868 NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20		EPS15_HUMAN (529-913): 1.04e-10: 68.9: 12.69
+	Dm
		112569 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Dm
		91154 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		E3CTP7_DROME (25-165): 8.27e-11: 69.2: 22.37
+	Mm
		956235 DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27		NCK1_MOUSE (889-1057): 2.15e-09: 63.5: 28.49
+	Hs
		269120 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Ce
		60780 A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25
+	Ce
		283754 CED6_CAEEL (5-428): 1.43e-35: 143: 16.47		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25
+	Ce
		1353620 NUMB1_CAEEL (23-530): 3.63e-34: 140: 11.50		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25