HitPredict

Interactor 1: E7EPI0 (E7EPI0)
Inhibitor of Bruton tyrosine kinase
Gene: IBTK

Interactor 2: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1338 Hs			1 857
+	Hs
		755642 IBTK_HUMAN (1-1338): 0: 1051: 98.89		TTK_HUMAN (1-857): 0: 778: 100.00
+	Hs
		1143104 IBTK_HUMAN (1-1338): 0: 1051: 98.89		KPCD1_HUMAN (175-857): 6.92e-134: 423: 15.61
+	Hs
		1146487 IBTK_HUMAN (1-1338): 0: 1051: 98.89		KS6A2_HUMAN (525-818): 6.44e-81: 277: 22.29
+	Hs
		329135 RCBT2_HUMAN (31-313): 5.01e-45: 174: 21.02		TTK_HUMAN (1-857): 0: 778: 100.00
+	Hs
		755644 HERC5_HUMAN (130-355): 2.6e-42: 170: 24.79		TTK_HUMAN (1-857): 0: 778: 100.00
+	Hs
		1096524 KLH20_HUMAN (716-1251): 8.27e-74: 260: 11.55		PAK1_HUMAN (239-800): 2.35e-117: 369: 18.39
+	Hs
		1110540 KLHL5_HUMAN (729-1176): 1.75e-74: 266: 12.61		KCC2D_HUMAN (519-856): 1.1e-113: 357: 22.95
+	Mm
		616121 SPOP_MOUSE (707-933): 1.09e-70: 243: 24.23		KS6A3_MOUSE (477-818): 6.98e-81: 277: 21.05
+	Hs
		1153235 HERC1_HUMAN (280-582): 1.58e-27: 124: 13.33		AKT3_HUMAN (468-857): 1.34e-119: 372: 18.05
+	Hs
		329148 RCBT2_HUMAN (31-313): 5.01e-45: 174: 21.02		ULK3_HUMAN (525-797): 3.61e-27: 117: 28.72