Protein: TTK
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)

Gene: TTK
Organism: Homo sapiens
Interactions: 177
UniProt ID: P33981

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

755523

TTK
Dual specificity protein kinase TTK

3

16

Small-scale

0.839

High

755554

SQSTM
Sequestosome-1

2

6

High-throughput

0.754

High

406872

MAS
Proto-oncogene Mas

2

8

High-throughput

0.726

High

466872

ACM4
Muscarinic acetylcholine receptor M4

2

4

High-throughput

0.726

High

720595

GRPR
Gastrin-releasing peptide receptor

2

4

High-throughput

0.726

High

755525

APJ
Apelin receptor

2

4

High-throughput

0.726

High

755533

NPY2R
Neuropeptide Y receptor type 2

2

4

High-throughput

0.726

High

755621

LPAR4
Lysophosphatidic acid receptor 4

2

7

High-throughput

0.726

High

755641

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

10

High-throughput

0.726

High

461197

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.724

High

182480

GP182
G-protein coupled receptor 182

1

11

High-throughput

0.691

High

638392

FPR1
fMet-Leu-Phe receptor

1

7

High-throughput

0.691

High

719765

V2R
Vasopressin V2 receptor

1

5

High-throughput

0.691

High

755530

GPR12
G-protein coupled receptor 12

1

4

High-throughput

0.691

High

755541

CXCR4
C-X-C chemokine receptor type 4

1

8

High-throughput

0.691

High

755649

NINL
Ninein-like protein

2

12

High-throughput

0.675

High

755639

S39A9
Zinc transporter ZIP9

3

4

High-throughput

0.662

High

755565

KS6A1
Ribosomal protein S6 kinase alpha-1

1

18

High-throughput

0.656

High

755567

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.656

High

667579

CDK2
Cyclin-dependent kinase 2

1

13

Small-scale

0.647

High

755572

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.647

High

718507

CDC27
Cell division cycle protein 27 homolog

3

9

Small-scale

0.640

High

755559

I13R2
Interleukin-13 receptor subunit alpha-2

2

5

High-throughput

0.628

High

755606

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

7

High-throughput

0.628

High

133228

P2Y10
Putative P2Y purinoceptor 10

1

9

High-throughput

0.618

High

755527

OPRX
Nociceptin receptor

1

5

High-throughput

0.618

High

755552

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

8

High-throughput

0.618

High

755594

AN36B
Ankyrin repeat domain-containing protein 36B

1

8

High-throughput

0.618

High

755651

NPTN
Neuroplastin

1

4

High-throughput

0.618

High

136057

PLK4
Serine/threonine-protein kinase PLK4

1

17

High-throughput

0.618

High

240886

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

375231

RASK
GTPase KRas

1

14

High-throughput

0.618

High

411457

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

541363

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

755526

CCNF
Cyclin-F

1

18

High-throughput

0.618

High

755544

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

755545

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.618

High

755557

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.618

High

755562

KIF14
Kinesin-like protein KIF14

1

12

High-throughput

0.618

High

755573

CE170
Centrosomal protein of 170 kDa

1

7

High-throughput

0.618

High

755590

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

755591

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

755617

AURKB
Aurora kinase B

1

17

High-throughput

0.618

High

755627

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.618

High

755628

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

9

High-throughput

0.618

High

755629

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

755637

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.618

High

755642

IBTK
Inhibitor of Bruton tyrosine kinase

1

8

High-throughput

0.618

High

755643

UBQL2
Ubiquilin-2

1

9

High-throughput

0.618

High

163899

NDC80
Kinetochore protein NDC80 homolog

2

11

Small-scale

0.613

High

755605

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

755608

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

755563

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.584

High

755633

CPAP
Centrosomal P4.1-associated protein

2

7

High-throughput

0.584

High

755646

FZR1
Fizzy-related protein homolog

2

9

Small-scale

0.584

High

755636

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.578

High

413289

P53
Cellular tumor antigen p53

1

8

Small-scale

0.578

High

755535

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.575

High

755538

VMAT1
Chromaffin granule amine transporter

2

3

High-throughput

0.574

High

755635

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

5

High-throughput

0.553

High

122718

KIF2A
Kinesin-like protein KIF2A

1

8

High-throughput

0.536

High

561917

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.536

High

698427

CALX
Calnexin

1

3

High-throughput

0.536

High

755529

UTRN
Utrophin

1

9

High-throughput

0.536

High

755543

RL7A
Large ribosomal subunit protein eL8

1

6

High-throughput

0.536

High

755548

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.536

High

755555

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

755560

ESPL1
Separin

1

2

High-throughput

0.536

High

755595

LRC25
Leucine-rich repeat-containing protein 25

1

1

High-throughput

0.536

High

755607

GEMI5
Gem-associated protein 5

1

6

High-throughput

0.536

High

755625

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.536

High

755631

CHODL
Chondrolectin

1

1

High-throughput

0.536

High

755644

HERC5
E3 ISG15--protein ligase HERC5

1

12

High-throughput

0.536

High

755575

CP135
Centrosomal protein of 135 kDa

2

7

High-throughput

0.533

High

755597

NIN
Ninein

2

15

High-throughput

0.533

High

755602

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

Small-scale

0.527

High

329135

RCBT2
RCC1 and BTB domain-containing protein 2

1

4

High-throughput

0.515

High

334278

TACC2
Transforming acidic coiled-coil-containing protein 2

1

5

Small-scale

0.515

High

642657

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.515

High

95877

E7EPI0
Inhibitor of Bruton tyrosine kinase

1

10

High-throughput

0.514

High

755592

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

755570

BOREA
Borealin

1

3

Small-scale

0.502

High

421591

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

667188

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.501

High

755528

RAD52
DNA repair protein RAD52 homolog

1

2

Small-scale

0.501

High

755650

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

2

Small-scale

0.501

High

755622

NUF2
Kinetochore protein Nuf2

1

10

Small-scale

0.500

High

706076

S10A2
Protein S100-A2

1

13

High-throughput

0.489

High

755534

PTH2R
Parathyroid hormone 2 receptor

1

3

High-throughput

0.489

High

755584

MTSS2
Protein MTSS 2

1

1

High-throughput

0.489

High

755600

SPC24
Kinetochore protein Spc24

1

0

Small-scale

0.479

High

755632

SPC25
Kinetochore protein Spc25

1

0

Small-scale

0.479

High

159530

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

293281

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315192

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

316764

MTA2
Metastasis-associated protein MTA2

1

4

High-throughput

0.479

High

326928

UBE4B
Ubiquitin conjugation factor E4 B

1

7

Small-scale

0.479

High

345430

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

395585

ESR1
Estrogen receptor

1

19

Small-scale

0.479

High

457258

TBB5
Tubulin beta chain

1

11

Small-scale

0.479

High

474512

VIME
Vimentin

1

20

High-throughput

0.479

High

483028

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

552514

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

555903

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

588026

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

613305

VINC
Vinculin

1

4

High-throughput

0.479

High

694740

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

755531

TISD
mRNA decay activator protein ZFP36L2

1

5

High-throughput

0.479

High

755537

FXR1
RNA-binding protein FXR1

1

19

High-throughput

0.479

High

755539

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

755542

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

755547

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

755549

CDC20
Cell division cycle protein 20 homolog

1

10

Small-scale

0.479

High

755550

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

755551

CDC16
Cell division cycle protein 16 homolog

1

10

Small-scale

0.479

High

755553

SMAD4
Mothers against decapentaplegic homolog 4

1

3

Small-scale

0.479

High

755556

CUL3
Cullin-3

1

6

High-throughput

0.479

High

755558

DCTN1
Dynactin subunit 1

1

13

High-throughput

0.479

High

755571

ODFP2
Outer dense fiber protein 2

1

6

High-throughput

0.479

High

755574

CE162
Centrosomal protein of 162 kDa

1

13

High-throughput

0.479

High

755577

FTM
Protein fantom

1

8

High-throughput

0.479

High

755581

SYNE3
Nesprin-3

1

11

High-throughput

0.479

High

755587

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

755588

CNTRL
Centriolin

1

8

High-throughput

0.479

High

755589

TAXB1
Tax1-binding protein 1

1

14

High-throughput

0.479

High

755598

CE120
Centrosomal protein of 120 kDa

1

15

High-throughput

0.479

High

755599

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.479

High

755609

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

755610

HS105
Heat shock protein 105 kDa

1

14

High-throughput

0.479

High

755612

ESR2
Estrogen receptor beta

1

18

High-throughput

0.479

High

755613

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

14

Small-scale

0.479

High

755614

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

15

High-throughput

0.479

High

755624

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.479

High

755626

VP33B
Vacuolar protein sorting-associated protein 33B

1

6

High-throughput

0.479

High

755630

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

755634

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

755648

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.479

High

755611

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

755620

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

755640

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

95886

E7EQ69
N-alpha-acetyltransferase 50

1

1

High-throughput

0.445

High

538733

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

6

High-throughput

0.445

High

755561

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

7

High-throughput

0.445

High

755586

SV2B
Synaptic vesicle glycoprotein 2B

1

9

High-throughput

0.445

High

755647

XCT
Cystine/glutamate transporter

1

6

High-throughput

0.445

High

324095

CE152
Centrosomal protein of 152 kDa

1

6

High-throughput

0.437

High

755524

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

755532

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.437

High

755536

VASP
Vasodilator-stimulated phosphoprotein

1

12

High-throughput

0.437

High

755546

PRB3
Basic salivary proline-rich protein 3

1

6

High-throughput

0.437

High

755564

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.437

High

755566

CCDC6
Coiled-coil domain-containing protein 6

1

10

High-throughput

0.437

High

755569

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

755576

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.437

High

755579

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

755580

FBX42
F-box only protein 42

1

9

High-throughput

0.437

High

755583

CE128
Centrosomal protein of 128 kDa

1

14

High-throughput

0.437

High

755593

CNTRB
Centrobin

1

11

High-throughput

0.437

High

755603

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.437

High

755604

PLPR1
Phospholipid phosphatase-related protein type 1

1

1

High-throughput

0.437

High

755615

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

755618

CEP63
Centrosomal protein of 63 kDa

1

10

High-throughput

0.437

High

755619

CEP89
Centrosomal protein of 89 kDa

1

10

High-throughput

0.437

High

755623

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.437

High

755645

ANC2
Anaphase-promoting complex subunit 2

1

9

High-throughput

0.437

High

628391

KLK2
Kallikrein-2

1

3

High-throughput

0.407

High

755585

SV2A
Synaptic vesicle glycoprotein 2A

1

6

High-throughput

0.407

High

755601

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High

755638

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

755596

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

62757

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.269

Low

755568

MOONR
Protein moonraker

1

0

High-throughput

0.249

Low

755578

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

755582

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

755616

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.249

Low

755540

S26A5
Prestin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025