HitPredict

Interactor 1: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Interactor 2: RAB7B (Q96AH8)
Ras-related protein Rab-7b
Gene: RAB7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	21988832
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 199
+	Hs
		988382 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB35_HUMAN (1-199): 2.56e-86: 254: 34.15
+	Mm
		956834 RAB8B_MOUSE (4-180): 2.41e-74: 223: 34.83		RAB35_MOUSE (1-199): 2.56e-86: 254: 34.15
+	Zm
		77342 B4FAE1_MAIZE (4-180): 2.1e-75: 226: 35.39		B4FAE1_MAIZE (1-199): 1.83e-84: 250: 34.15
+	Mm
		981401 RAB1A_MOUSE (4-183): 1.58e-73: 221: 31.49		RAB35_MOUSE (1-199): 2.56e-86: 254: 34.15
+	Dm
		197040 RAP1_DROME (1-166): 1.39e-82: 243: 90.36		O18332_DROME (2-199): 1.89e-76: 229: 34.80
+	Hs
		981255 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB1A_HUMAN (1-199): 2.31e-80: 239: 34.63
+	Hs
		988691 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB1B_HUMAN (1-199): 1.23e-79: 237: 34.80
+	Mm
		981416 RAB1A_MOUSE (4-183): 1.58e-73: 221: 31.49		RAB1B_MOUSE (1-199): 1.45e-79: 237: 34.31
+	Hs
		976191 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RB11A_HUMAN (2-199): 6.37e-75: 226: 25.00
+	Hs
		955911 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB8A_HUMAN (1-197): 4.42e-74: 223: 31.68
+	Hs
		988393 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RB11B_HUMAN (2-199): 6.53e-74: 223: 25.23
+	Hs
		959313 RAP1B_HUMAN (1-184): 1.97e-74: 223: 100.00		RB11A_HUMAN (2-199): 6.37e-75: 226: 25.00
+	Hs
		955910 RAB1A_HUMAN (4-183): 1.58e-73: 221: 31.49		RAB8A_HUMAN (1-197): 4.42e-74: 223: 31.68
+	Hs
		901174 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB7A_HUMAN (1-189): 8.36e-61: 190: 50.00
+	Hs
		901759 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB9A_HUMAN (9-199): 6.76e-46: 152: 42.64
+	Hs
		901758 RAB1A_HUMAN (4-183): 1.58e-73: 221: 31.49		RAB9A_HUMAN (9-199): 6.76e-46: 152: 42.64
+	Hs
		988349 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB32_HUMAN (9-199): 4.88e-35: 124: 35.32
+	Hs
		988812 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RAB23_HUMAN (6-186): 8.47e-35: 124: 35.87
+	Hs
		630749 RAP1B_HUMAN (1-184): 1.97e-74: 223: 100.00		RAB4A_HUMAN (9-177): 1.96e-35: 125: 39.41
+	Hs
		630754 RAB1A_HUMAN (4-183): 1.58e-73: 221: 31.49		RAB4A_HUMAN (9-177): 1.96e-35: 125: 39.41