HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PARD3 (Q8TEW0)
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Gene: PARD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0030054 - cell junction and 1 others more... GO:0043296 - apical junction complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1356
+	Hs
		988553 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		466378 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		1015627 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		962308 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PAR3L_HUMAN (1-1353): 6.79e-109: 374: 33.38
+	Hs
		466379 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		PAR3L_HUMAN (1-1353): 6.79e-109: 374: 33.38
+	Hs
		962343 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		DLG3_HUMAN (556-1119): 1.07e-27: 123: 13.64
+	Mm
		988891 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		DLG4_MOUSE (540-699): 7.92e-23: 107: 27.98
+	Hs
		961996 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		962291 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		INADL_HUMAN (28-355): 2.99e-16: 87: 11.64
+	Hs
		962401 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MAGI1_HUMAN (413-780): 3.17e-16: 87: 15.48
+	Hs
		988322 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		988627 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MAGI1_HUMAN (413-780): 3.17e-16: 87: 15.48
+	Hs
		466227 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		961986 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ZO1_HUMAN (271-1335): 2.77e-12: 73.9: 9.16
+	Hs
		466372 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		LNX1_HUMAN (73-395): 5.04e-14: 79.3: 13.74
+	Dm
		828001 RAC1_DROME (1-193): 1.51e-76: 229: 54.12		SCRIB_DROME (554-719): 3.84e-13: 76.7: 22.49
+	Hs
		962039 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		988360 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		466247 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		1015432 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96