Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 11724934, 20705607, 15280377, 14517261, 25888903, 25809483, 25659040, 27215386, 28166445, 28196907, 26720344, 29057323, 23695783, 10722742, 32075226, 32211658, 32350255, 32904724, 19166840, 33450248 and 38 others

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Identification Methods enzymatic study, protein complementation assay, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, unspecified method, anti tag coimmunoprecipitation, two hybrid array, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SWIB~SWIB, zf-C3HC4_3~zf-C3HC4_3
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0001568 - blood vessel development
GO:0001974 - blood vessel remodeling
GO:0002027 - regulation of heart rate
and 83 others

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Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 491
Hs

1 491
+ Mm
+ Hs
+ Mm
+ Hs
+ Dr

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024