Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.99 | 1.00 | 0.997 |
The method score is based on:
Property | Details |
---|---|
Experiments | 11724934, 20705607, 15280377, 14517261, 25888903, 25809483, 25659040, 27215386, 28166445, 28196907, 26720344, 29057323, 23695783, 10722742, 32075226, 32211658, 32350255, 32904724, 19166840, 33450248 and 38 others
more... |
Identification Methods | enzymatic study, protein complementation assay, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, unspecified method, anti tag coimmunoprecipitation, two hybrid array, anti bait coimmunoprecipitation |
Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | SWIB~SWIB, zf-C3HC4_3~zf-C3HC4_3 |
Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000209 - protein polyubiquitination GO:0001568 - blood vessel development GO:0001974 - blood vessel remodeling GO:0002027 - regulation of heart rate and 83 others more... |
Homologous interactions | 5 |
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024